Protein cleaved~DFFA* map

Identifiers
DNA fragmentation factor, 45kDa, alpha polypeptide
HUGO:DFFA HGNC:2772 ENTREZ:1676 UNIPROT:O00273

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

cleaved~DFFA*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

References
rc_re687( Regulated Cell Death  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:9108473
purification of DFFA:DFFB activity from Hela cells cytosol
in vitro, CASP3 mediated of DFFA necessary for nucleosomal DNA fragmentation
in U937 monocyte cells, in Hela cells, in SV589 human fibroblasts, upon staurosporin, DFFA cleaved into the same fragments as in vitro
PMID:9422506
purification and cloning of ICAD:CAD (mouse homologs) from mouse T-cell lymphoma cytosol
CASP3-mediated cleavage of ICAD releases CAD, leading to activation of its enzymatic activity and its nuclear localization

Modifications:
In compartment: Cytosol
  1. cleaved~DFFA*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. DFFA:​DFFB@Cytosol map → map DFFB@Cytosol map + cleaved~DFFA*@Cytosol map
    As Catalyser: