Complex IL10:IL10RA:IL10RB map
Complex composition:

  1. IL10 map
  2. IL10RB map
  3. IL10RA map

IL10:​IL10RA:​IL10RB@Membrane

Identifiers
NAME:IL10:IL10RA:IL10RB

Maps_Modules
MODULE:MACROPHAGE

References
PMID:21115385,PMID:10433356
IL10??? ???acts via IL10??? ???receptor.
IL10??? ???first binds to IL10RA
The IL10/IL10R1A ???interaction changes the cytokine
conformation allowing the association of
the IL10/IL10RA ???complex with IL10RB.
PMID:???15833879
???Anti IL-10 receptor???specific antibody
switched TAMs from an M2 to an M1
macrophage???like phenotype.

Modifications:
Participates in complexes:
In compartment: Membrane
  1. IL10:​IL10RA:​IL10RB@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL10@default map + IL10RA:​IL10RB@Membrane map → map IL10:​IL10RA:​IL10RB@Membrane map
  2. IL10:​IL10RA:​IL10RB@Membrane map + JAK1@Membrane map + TYK2@Membrane map → map IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
As Catalyser: