Protein HCLK2* map

Identifiers
TEL2, telomere maintenance 2, homolog (S. cerevisiae)
Protein clk-2 homolog , HCLK2
HUGO:TELO2, HGNC:29099, ENTREZ:9894, UNIPROT:Q9Y4R8

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map

References
PMID:19686080, PMID:19622404, PMID:18931676
For regulation of Fanconi pathway via cell cycle
PMID:18995830, PMID:17384638
For S-phase checkpoint
PMID:17384638, PMID:19793801
HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase
PMID:19282663, PMID:19622404

HCLK2*@Nucleus

References
ce_re199( Cell Cycle DNA Repair  map ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
ce_re463( Cell Cycle DNA Repair  map ):
Arrests cell cycle in S-phase in response to stalled replication fork or ds breaks in DNA:
PMID:15459660, PMID:17384638, PMID:19793801

Modifications:
In compartment: Nucleus
  1. HCLK2*@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@Nucleus map
  2. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. HCLK2*@Nucleus map + FAAP24*@Nucleus map + FANCM@Nucleus map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@Nucleus map
  2. HCLK2*@Nucleus map + CLSPN|​pho@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@Nucleus map
As Catalyser:
  1. S phase@Nucleus map → map G2 phase@Nucleus map