Reaction state_transition ce_re65 map

CDC25A@Nucleus map → CDC25A|​S76_pho|​S178_pho|​S124_pho|​S279_pho|​S293_pho@Nucleus map

Reaction regulators:
Catalysis
  1. CHEK2|​pho|​active@Nucleus map
  2. CHEK1|​pho|​active@Nucleus map


References
Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C
and stops cell cycle propagation
kegg cell cycle
PMID:20126263, PMID:17568790