Complex CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*
Complex composition:
- CDT1
- POLA*
- PRIM*
- ORC4*
- ORC5*
- ORC6*
- MCM5
- MCM3
- MCM6
- MCM4
- MCM7
- MCM2
- ORC3*
- ORC2*
- ORC1*
- CDC6
- CDC45
CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*@Nucleus
Identifiers
NAME:CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair
/ S_CC_PHASE
References
ce_re355( Cell Cycle DNA Repair
):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
ce_re437( Cell Cycle DNA Repair
):
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
Stalled replication forks induce PCNA mono-ubiquitylation and formation of the complex that activated TLS and arrests S-phase:
PMID:19793801, PMID:17582221, PMID:19158510, PMID:18451105
Modifications:
Participates in complexes:
In compartment: Nucleus
- CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*@Nucleus
Participates in reactions:
As Reactant or Product:- ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*@Nucleus
+ MCM2:MCM3:MCM4:MCM5:MCM6:MCM7@Nucleus
+ CDT1@Nucleus
+ CDC6@Nucleus
+ CDC45@Nucleus
+ POLA*@Nucleus
+ PRIM*@Nucleus
+ RPA1@Nucleus
+ RPA2@Nucleus
+ RPA3@Nucleus
→
CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*@Nucleus
As Catalyser:- No DNA replicarion@Nucleus
→
DNA replicarion@Nucleus