Complex ATR:ATRIP:CHEK1:CLSPN:TIM1*:TIPIN map
Complex composition:

  1. ATRIP map
  2. CHEK1 map
  3. ATR map
  4. TIM1* map
  5. TIPIN map
  6. CLSPN map

ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus

Identifiers
NAME:ATR:ATRIP:CHEK1:CLSPN:TIM1*:TIPIN

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map

References
Stalled replication forks or double strand breaks in the S-phase re-orient activity of TIM1*/TIPIN from the DNA replication to DNA repair.
TIM1*/TIPIN as part of this complex inhibits teplication and stablises stalled replication forks till DNA damage is repaired
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104
ce_re119( Cell Cycle DNA Repair  map ):
For inhibition of S-checkpoint by ATM:
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
ce_re355( Cell Cycle DNA Repair  map ):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. ATRIP:​ATR|​pho:​CLSPN|​pho@Nucleus map + TIPIN@Nucleus map + TIM1*@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus map
As Catalyser:
  1. S phase@Nucleus map → map G2 phase@Nucleus map
  2. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@Nucleus map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@Nucleus map + CDT1@Nucleus map + CDC6@Nucleus map + CDC45@Nucleus map + POLA*@Nucleus map + PRIM*@Nucleus map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map → map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*@Nucleus map