Protein POLA*
Identifiers
polymerase (DNA directed), alpha 1, catalytic subunit
HUGO:POLA1, HGNC:9173, ENTREZ:5422, UNIPROT:P09884
polymerase (DNA directed), alpha 2 (70kD subunit)
HUGO:POLA2, HGNC:30073, ENTREZ:23649, UNIPROT:Q14181
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair
/ S_CC_PHASE
References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786
POLA*@Nucleus
References
ce_re355( Cell Cycle DNA Repair
):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
Modifications:
In compartment: Nucleus
- POLA*@Nucleus
Participates in complexes:
In compartment: Nucleus
- CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*@Nucleus
Participates in reactions:
As Reactant or Product:- ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*@Nucleus
+ MCM2:MCM3:MCM4:MCM5:MCM6:MCM7@Nucleus
+ CDT1@Nucleus
+ CDC6@Nucleus
+ CDC45@Nucleus
+ POLA*@Nucleus
+ PRIM*@Nucleus
+ RPA1@Nucleus
+ RPA2@Nucleus
+ RPA3@Nucleus
→
CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*@Nucleus
As Catalyser:- No DNA replicarion@Nucleus
→
DNA replicarion@Nucleus