Protein FANCA map

Identifiers
Fanconi anemia, complementation group A
HUGO:FANCA, HGNC:3582, ENTREZ:2175, UNIPROT:Q9UEL9

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / FANCONI  map
 Cell Cycle DNA Repair  map  / TLS  map

References
PMID:19686080, PMID:19622404, PMID:18931676
FA core complex regulates REV1 and activated TLS
PMID:22266823

FANCA|​pho@Nucleus

References
ce_re186( Cell Cycle DNA Repair  map ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
ce_re162( Cell Cycle DNA Repair  map ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404

FANCA@Nucleus

References
ce_re525( Cell Cycle DNA Repair  map ):
HSP90 redirects FANCA to degradation, inhibits Fanconi pathway and increases sensitivity to cross-linking agents
PMID:17327415

Modifications:
In compartment: Nucleus
  1. FANCA@Nucleus map
  2. FANCA|​pho@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. FANCA|​pho:​FANCG|​S7_pho@Nucleus map
  2. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​TOP3A@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. FANCG|​S7_pho@Nucleus map + FANCA|​pho@Nucleus map → map FANCA|​pho:​FANCG|​S7_pho@Nucleus map
  2. FANCA|​pho:​FANCG|​S7_pho@Nucleus map + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@Nucleus map + FAAP24*:​FANCM@Nucleus map + FAAP100*:​FANCB:​FANCL@Nucleus map + BLM@Nucleus map + HES1@Nucleus map + FAAP20*@Nucleus map → map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map
  3. FANCA@Nucleus map → map FANCA|​pho@Nucleus map
  4. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map + TOP3A@Nucleus map + RPA1:​RPA2:​RPA3@Nucleus map → map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​TOP3A@Nucleus map
  5. FANCA@Nucleus map → map FANCA@Nucleus map
  6. FANCA@Nucleus map → map degraded
As Catalyser:
  1. gFanconi_DNA_st2*@Nucleus map → map gFanconi_DNA_st3*@Nucleus map
  2. FANCD2|​pho@Nucleus map → map FANCD2|​K561_ubi|​pho@Nucleus map
  3. FANCI|​pho@Nucleus map → map FANCI|​K523_ubi|​pho@Nucleus map
  4. gFanconi_DNA_st3*@Nucleus map → map gFanconi_DNA_st4*@Nucleus map
  5. gFanconi_DNA_st4*@Nucleus map → map gFanconi_DNA_st5*@Nucleus map
  6. FANCD2@Nucleus map → map FANCD2|​pho@Nucleus map
  7. FANCD2|​K561_ubi|​pho@Nucleus map + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  8. gTLS_DNA_st1*@Nucleus map → map gTLS_DNA_st2*@Nucleus map