Reaction heterodimer_association ce_re355 map

ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@Nucleus map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@Nucleus map + CDT1@Nucleus map + CDC6@Nucleus map + CDC45@Nucleus map + POLA*@Nucleus map + PRIM*@Nucleus map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map → CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*@Nucleus map

Reaction regulators:
Catalysis
  1. PP2A*@Nucleus map
  2. CDC7:​DBF4@Nucleus map
  3. (CDK2|​T160_pho:​CyclinE*)|​active@Nucleus map
  4. (CDK2|​T160_pho:​CyclinA1*)|​active@Nucleus map
  5. (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@Nucleus map
  6. RPA1:​RPA2:​RPA3@Nucleus map
Inhibition
  1. HUS1:​RAD1:​RAD17:​RAD9*:​RFC*@Nucleus map
  2. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus map


References
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221