AXIN1

Protein AXIN1

Identifiers
axin 1
HUGO:AXIN1, HGNC:903, ENTREZ:8312, UNIPROT:O15169??, GENECARDS:GC16M000338
HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / ADHERENS_JUNCTIONS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_NON_CANONICAL

References
PMID:19751508
PMID:22270359
PMID:16940750
in the absence of Wnt ligands, b-catenin is phosphorylated by CK1 and GSK-3 in the context of a destruction complex with APC and Axin.
Phosphorylated b-catenin is consequently targeted for ubiquitination and degraded.
Upon ligand binding (right panel), DVL1 (dishevelled) recruits the Axin-GSK-3 complex, resulting in the sequential phosphorylation of LRP6 by CK1 and GSK-3.
Phoshorylated LRP6 serves as a docking site for additional Axin-GSK-3 complex, resulting in the disassembly of the destruction complex.
Non phosphorylated and thus stabilized b-catenin translocates to the nucleus where it activates transcription of target genes together with LEF/TCFs

AXIN1@Cytosol

References
em_emtc_emtc_re466( EMT Senescence ):
PMID:10428961
PMID:8666229
Wnt transduces their signals through DVL1 to inhibit GSK3B, leading to the accumulation of cytosolic CTNNB1 and activation of TCF/LEF1 transcription factors.
DVL1 interacts with AXIN1 and with Frat1.
Binding of AXIN1 to DVL1 reduces formation of the destruction complex APC/AXIN1.
em_emtc_emtc_re1011( EMT Senescence ):
PMID:10581160
PMID:17318175
PMID:10421629
Recruitment of CTNNB1 via the degradation complex of APC/AXIN1 is regulated by a series of ordered phosphorylation events.
Phosphorylation of AXIN1 by CSNK1 (casein kinase 1) and GSK3B can increase axin binding to CTNNB1.
PMID:8638126
PMID:11487578
PMID:15327768
AXIN1 also promotes phosphorylation of APC by CSNK1 and GSK3B.
Phosphorylated APC has higher affinity to CTNNB1.
PMID:12554650
Finally, these phosphorylation events allo CTNNB1 to be a more efficient substrate of both CSNK1 (at S45) and the GSK3B (at T41, S33, S37).
The affinity of phosphorylated APC to CTNNB1 is higher than that of phosphorylated AXIN1.
Therefore upon phosphorylation, APC can displace AXIN1 from CTNNB1, allowing AXIN1 to bind another molecule of CTNNB1.

AXIN1@Nucleus

References
s_wnc4_re13:( Survival ) PMID:19131971

Modifications:
In compartment: Cytosol

AXIN1@Cytosol

In compartment: Nucleus

AXIN1@Nucleus

Participates in complexes:
In compartment: Cytosol

In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: