Identifiers
v-myc myelocytomatosis viral oncogene homolog (avian)
HUGO:MYC, HGNC:7553, ENTREZ:4609, GENECARDS:GC08P128748, UNIPROT:P01106??????
v-myc avian myelocytomatosis viral oncogene homolog
HUGO:MYC
HUGO:MYC, HGNC:7553, ENTREZ:4609, UNIPROT:P01106
"v-myc avian myelocytomatosis viral oncogene homolog"
HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / METABOLIC
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G1_S_CHECKPOINT
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MITOCHONDRIAL_GENES
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
Innate Immunity / MIRNA_TF_IMMUNOSUPPRESSIVE
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / WNT_NON_CANONICAL
References
PMID:25002027
We found significantly reduced levels of c-Myc in p62 KO fibroblasts as well as in WT fibroblasts in which p62 has been knocked down by shRNA
PMID:11283614
Myc: an ubiquitous mediator of cell growth and proliferation
Myc can both activate and repress transcription, depending on the nature of associated factors
TGFB downregulates Myc to cause cell cycle arrest.
TGFB activates p15INK4B and/or p21CIP1 (inhibitor of CDKs) ==> CDK inhibition by TGFB
TGFB downregulates cdc25A (a phosphatase, activator of CDKs) ==> CDK inhibition by TGFB
PMID:2191300
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
PMID??:28536364
c-myc is transcriptionally upregulated by NF-??B
PMID:20027199
MYC induces DNA damage throuh an increase in ROS production, innapropriate DNA synthesis and abrogation of DNA repair
PMID:20713526
MYC supress the activity of anti-apoptotic BCL2 and BCLXL (BCL2L1) genes
PMID??:20713526
MYC in complex with CDK2 alone inhibit senescence through the inhibition of p16 and p21 expression as well as TERT and BMI1 expression increase. MYC in complex with CDK2 and p27KIP1 induces senescence through the expression increase of p16 and p21 as well as TERT and BMI1 expression decrease. WRN inhibit MYC induced senescence.
PMID??:17055429
MYC stimulate P53 and ARF(CDKN2A)
PMID:20551172, PMID:21406394, PMID:17873522, PMID:17558397
PMID:22067385
c-MYC expression is assosiated with M2 type of macrophages.
IL4 induces MYC expression in macrophages. MYC directly regulates some genes associated with alternative activation, including SCARB1, ALOX15, and MRC1, whereas others, including CD209, are indirectly regulated by c-MYC. c-MYC up-regulates the IL-4 signaling mediators signal transducer and activator of transcription-6 and peroxisome proliferator-activated receptor??, is also expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:20581311
STAT3 as an essential mediator of emergency granulopoiesis by its regulation of transcription factors that direct G-CSF-responsive myeloid progenitor expansion.
STAT3 directly controls G-CSF-dependent expression of CCAAT-enhancer-binding protein ?? (C/EBP??), a crucial factor in the emergency granulopoiesis response. Moreover, STAT3 and C/EBP?? coregulate c-Myc through interactions with the c-myc promoter that control the duration of C/EBP?? occupancy during demand-driven granulopoiesis.
PMID:20237412
IFN-?? regulates expression of homing and angiogenic factors in neutrophils.
IFNB downregulates expression Cxcr4, Vegf, and Mmp9 in neutrophils
additionally Stat3 and c-myc are downregulated by IFN-??.
(STAT3 is known to be required for full activation of the Cxcr4 gene )
C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts.
PMID:11274345
References
em_re1538( EMT Senescence ):
PMID:2191300
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
PMID:28536364 c-myc is also transcriptionally upregulated by NF-??B
em_emtc_emtc_re280( EMT Senescence ):
PMID:11283613
Miz-1 regulates expression of p15INK4b
A Myc???Miz-1 complex binds to the p15 promoter
Myc inhibits binding of p300 to Miz-1
Myc inhibits expression of p15INK4B by binding to Miz-1 (Myc represses p15INK4B by interacting with Miz1)
PMID:11283614
Miz1: a Myc-interacting Zinc-finger protein that recognizes certain transcriptional initiator elements
One of this transcriptional initiator element contains the sequence 5'-CCCACTCTGC corresponding to the p15INK4B transcriptional intiator
em_re1546( EMT Senescence ):
PMID:11704864
Transcriptional regulation of bcl-2 by nuclear factor kappa B
PMID:20713526
MYC supress the activity of anti-apoptotic BCL2 and BCLXL (BCL2L1) genes
em_re1592( EMT Senescence ):
CDK2 bind and phosphorylate MYC. Both CDK2 and phosphorylated MYC inhibit senescence genes
Myc: an ubiquitous mediator of cell growth and proliferation
Myc can both activate and repress transcription, depending on the nature of associated factors
TGFB downregulates Myc to cause cell cycle arrest.
TGFB activates p15INK4B and/or p21CIP1 (inhibitor of CDKs) ==> CDK inhibition by TGFB
TGFB downregulates cdc25A (a phosphatase, activator of CDKs) ==> CDK inhibition by TGFB
PMID:28536364
c-myc is transcriptionally upregulated by NF-??B
PMID:20027199
MYC induces DNA damage throuh an increase in ROS production, innapropriate DNA synthesis and abrogation of DNA repair
MYC in complex with CDK2 alone inhibit senescence through the inhibition of p16 and p21 expression as well as TERT and BMI1 expression increase. MYC in complex with CDK2 and p27KIP1 induces senescence through the expression increase of p16 and p21 as well as TERT and BMI1 expression decrease. WRN inhibit MYC induced senescence.
PMID:17055429
MYC stimulate P53 and ARF
em_re1603( EMT Senescence ):
PMID??: PMID:17055429
MYC stimulate P53 and ARF (CDKN2A)
PMID??:24954210??
DNA damage may reduce ARF (=p14 ARF) protein levels by inducing its degradation
em_re1604( EMT Senescence ):
MYC induces senescence through ROS production
em_re1618( EMT Senescence ):
p27KIP1* bind CDK2. The inhibition of CDK2 by p27KIP1*, allows MYC to exert its pro-senescence effect
PMID??:28536364
PMID??:20713526
References
ce_re404( Cell Cycle DNA Repair ):
Acetylation of c-Myc keeps it inactive and prevents G1/S propagation
PMID:15522869
References
in_re629( Innate Immunity ):
PMID:11875494
HMOX1 (HO1) mediates IL-10-induced suppression
of MMP9 expression.
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.
in_re631( Innate Immunity ):
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages via TLR4-dependent mechanisms.
PMID:21765015
CSF2 upregulates VEGF expression via HIF1a specific inhibition of PHD2 increases VEGF production
in_re1039( Innate Immunity ):
PMID:23390297
MIF induces expression of M2 markers ARG1, IL10, stabilin-1, MRC-1, CD23.
in_re1100( Innate Immunity ):
PMID:23124025
IL13 induces expression of MAOA and ALOX15 via JAK1, TYK2, STAT1 STAT3 and STAT6
IL4 induces expression of MAOA and ALOX15 via JAK1, STAT3 and STAT6.
in_re1103( Innate Immunity ):
in_re1107( Innate Immunity ):
PMID:10432118, PMID:21093321
IL4 upregulates expression of PPARG via JAK3/STAT6 pathway
in_re1364( Innate Immunity ):
PMID:16327802
IL13 and TNF together (but neither IL-13 nor TNF alone) upregulates TGFB1 expression downstream of IL13RA2.
IL13 and TNF inducese TGFB1 expression via AP-1 transcription factors.IL13 induces binding of c-jun and fra2 ti TGFB1 promotor, and TNF binding of c-jun, JunD and c-fos.
References
s_wnc4_re13:( Survival ) PMID:19131971
References
s_wnc4_re17:( Survival ) PMID:16969074
References
s_wnc4_re17:( Survival ) PMID:16969074
→ MYC@Cytosol
→ ce_s2495
+ MIZ1*@Nucleus + PKMYT1@Nucleus → ce_s2499
→ MYC|ace@Nucleus
+ p107*@Nucleus → ce_s2507
→ MYC@Nucleus
+ MYC@Nucleus → MIZ1*:MYC@Nucleus
→ MYC@Nucleus
+ CDK2@Cytosol → CDK2:MYC|pho@Nucleus
→ ROS@Mitochondria
→ DNA damage@Nucleus
+ MYC@Nucleus → CDK2:MYC:p27KIP1*@Nucleus
→ MYC@INNATE_IMMUNE_CELL_Cytosol
→ MYC@Nucleus
→ MYC@Cytosol
+ p14ARF*@Nucleus → rc_s3238
MYC@Nucleus
→ rc_s3297
→ gp14INK4A*@Nucleus
→ MYC@Nucleus
→ Proliferation@Cytoplasm
→ Cell cycle pathway@Nucleus
+ AXIN1@Nucleus + GSK3*@Nucleus + PIN1@Nucleus → AXIN1:GSK3*:MYC|S62_pho:PIN1@Nucleus
→ AXIN1:GSK3*:MYC|S62_pho|T58_pho:PIN1@Nucleus
→ AXIN1:GSK3*:MYC|S62_emp|T58_pho:PIN1@Nucleus
→ MYC|S62_emp|T58_pho@Nucleus + AXIN1@Nucleus + PIN1@Nucleus + GSK3*@Nucleus
→ MYC|S62_emp|T58_pho|K63_ubi@Nucleus
→ degraded
+ MAX@Nucleus → te_s488
→ rGLS@Cytosol
→ rBMI1@Nucleus
→ rp16INK4A*@Nucleus
→ rPTP4A3@Nucleus
→ rp15INK4B*@Nucleus
→ rp21CIP1*@Nucleus
→ rBCL2@Nucleus
→ p14ARF*@Cytosol
→ rBCL2-XL*@Nucleus
→ rTERT@Nucleus
→ rMRC1@MARKERS_MACROPHAGE
→ rMAOA@INNATE_IMMUNE_CELL_Cytosol
→ rALOX15@INNATE_IMMUNE_CELL_Cytosol
→ rPPARG@INNATE_IMMUNE_CELL_Cytosol
→ rCD209@MARKERS_MACROPHAGE
→ rTGFB1@INNATE_IMMUNE_CELL_Cytosol
→ rSTAT6@INNATE_IMMUNE_CELL_Cytosol
→ rMMP9@INNATE_IMMUNE_CELL_Cytosol
→ rVEGFA@INNATE_IMMUNE_CELL_Cytosol
→ rHIF1A@INNATE_IMMUNE_CELL_Cytosol
→ rCFLAR@Nucleus
→ p14ARF*|ubi@Nucleus
→ rp14ARF*@Nucleus
→ arMIR17-92*@Nucleus
→ rPDK1@Nucleus
→ rGPI@Nucleus
→ rTPI1@Nucleus
→ rLDHA@Nucleus
→ rGAPDH@Nucleus
→ rPFKM@Nucleus
→ rNDUFAF2@Nucleus
→ rCaspase8*@Nucleus
→ rSLC38A5@Nucleus
→ rSLC1A5@Nucleus
→ arMIR23A@Cytosol
→ rpre-mRNA~APO*@Nucleus
→ rPRDX3@Nucleus
→ rCytochrome_C*@Nucleus