Complex AXIN*:CK1_alpha_*:GSK3*
Complex composition:
- CK1_alpha_*
- AXIN*
- GSK3*
AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
Identifiers
NAME:AXIN*:CK1_alpha_*:GSK3*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
References
PMID:21606194
s_wca1_re34( Survival
):
PMID:21498506
Membrane-bound AMER1 acts as scaffold and brings APC to the membrane
s_wca1_re45:( Survival
) PMID:20460648 PMID:18077588 PMID:19705439 PMID:17426148
s_wca2_re65( Survival
):
Ubiquitination increases binding of APC with AXIN.
PMID:23277359
AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
Identifiers
NAME:AXIN*:CK1_alpha_*:GSK3*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
Modifications:
Participates in complexes:
In compartment: Cytoplasm
- AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
- AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
Participates in reactions:
As Reactant or Product:- AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
+ APC@Cytoplasm
+ AMER1*@Cytoplasm
→
AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- CK1_alpha_*@Cytoplasm
+ AXIN*@Cytoplasm
+ GSK3*@Cytoplasm
→
AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
- GTP:G_alpha_o*@Cytoplasm
+ AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
+ _beta_-Arrestin2*@Cytoplasm
→
AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm
- APC|K63_ubi@Cytoplasm
+ AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
→
APC|K63_ubi:AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
As Catalyser: