Protein GSK3_alpha_* map

Identifiers
glycogen synthase kinase 3 alpha
HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840
HUGO:GSK3A
HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A
ENTERZ:2931

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:16713974
AKT kinases phosphorylate GSK3 proteins and inhibit its activity downstream of TLR signaling.
IFNG prevents this inactivation.

GSK3_alpha_*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re40( Regulated Cell Death  map ):
logical:re40_s128_re45=FALSE
PMID:16543145
in different IL-3 dependent mouse pro-B cell lines upon IL-3 withdrawal
in Hela and 293T
S159 phosphorylation site correspond to human MCL1
GSK3A and GSK3B KD in NIH3T3
rc_re327:( Regulated Cell Death  map ) PMID:9065430
rc_re1997:( Regulated Cell Death  map ) PMID:22841746

GSK3_alpha_*|​S21_pho@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re327:( Regulated Cell Death  map ) PMID:9065430

GSK3_alpha_*|​pho@INNATE_IMMUNE_CELL_Cytosol

References
in_re1155( Innate Immunity  map ):
PMID:16713974
AKT kinases phosphorylate GSK3 proteins and inhibit its activity downstream of TLR signaling.
IFNG prevents this inactivation.

GSK3_alpha_*@INNATE_IMMUNE_CELL_Cytosol

References
in_re1155( Innate Immunity  map ):
PMID:16713974
AKT kinases phosphorylate GSK3 proteins and inhibit its activity downstream of TLR signaling.
IFNG prevents this inactivation.

GSK3_alpha_*@Cytoplasm

References
s_wnc1_re158( Survival  map ):
Mechanism is unknown, it is speculate that translocalisation occurs through calpain-sensitive proteins.
PMID:21266584

GSK3_alpha_*@Nucleus

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_NON_CANONICAL  map

References
It is explicitly, only GSK-3 alpha that is translocated
PMID:21266584
s_wnc1_re158( Survival  map ):
Mechanism is unknown, it is speculate that translocalisation occurs through calpain-sensitive proteins.
su_wnc1_s_wnc1_re158( Survival  map ):

Modifications:
In compartment: Cytoplasm
  1. GSK3_alpha_*@Cytoplasm map
In compartment: Cytosol
  1. GSK3_alpha_*@Cytosol map
  2. GSK3_alpha_*|​S21_pho@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GSK3_alpha_*@INNATE_IMMUNE_CELL_Cytosol map
  2. GSK3_alpha_*|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. GSK3_alpha_*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GSK3_alpha_*@INNATE_IMMUNE_CELL_Cytosol map → map GSK3_alpha_*|​pho@INNATE_IMMUNE_CELL_Cytosol map
    2. GSK3_alpha_*@INNATE_IMMUNE_CELL_Cytosol map → map GSK3*@INNATE_IMMUNE_CELL_Cytosol map
    3. GSK3_alpha_*@Cytosol map → map GSK3_alpha_*|​S21_pho@Cytosol map
    4. GSK3_alpha_*@Nucleus map → map GSK3_alpha_*@Cytoplasm map
    5. GSK3_alpha_*@Cytoplasm map → map GSK3_alpha_*@Nucleus map
    As Catalyser:
    1. GYS1@Cytosol map → map GYS1|​pho@Cytosol map
    2. MCL1@Mitochondrial inner membrane map → map MCL1|​S159_pho@Mitochondrial inner membrane map