Complex APC:AXIN*:CK1_alpha_*:GSK3*
Complex composition:
- AXIN*
- CK1_alpha_*
- APC
- GSK3*
APC|K63_ubi:AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
Identifiers
NAME:APC:AXIN*:CK1_alpha_*:GSK3*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
References
s_wca2_re65( Survival
):
Ubiquitination increases binding of APC with AXIN.
PMID:23277359
s_wca2_re66:( Survival
) The destruction is part of the canonical wnt pathway when no WNT ligand is bound to the receptor. This complex makes sure that beta-catenin is degraded.
Modifications:
Participates in complexes:
In compartment: Cytoplasm
- APC|K63_ubi:AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
Participates in reactions:
As Reactant or Product:- APC|K63_ubi@Cytoplasm
+ AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
→
APC|K63_ubi:AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
- APC|K63_ubi:AXIN*:CK1_alpha_*:GSK3*@Cytoplasm
→
WNT canonical pathway@Cytoplasm
As Catalyser: