ASK1*

Protein ASK1*

Identifiers
mitogen-activated protein kinase kinase kinase 5
HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683
MEKK5
HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 GENECARDS:MAP3K5 KEGG:4217 ATLASONC:GC_MAP3K5 WIKI:MAP3K5

Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DEPENDANCE_RECEPTORS
Regulated Cell Death / FAS_RESPONSE
Regulated Cell Death / ER_STRESS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_NON_CANONICAL

References
PMID:23850759
synonym:ASK1

ASK1*@Cytosol

ASK1*|unk|S967_pho@Cytosol

References
rc_re1309:( Regulated Cell Death ) PMID:10411906
rc_re1311( Regulated Cell Death ):
PMID:10411906
in Hela, overexpression of 14-3-3 isoform YWHAZ suppresses ASK1 overexpression-induced apoptosis
PMID:18292600
by PP2A
PMID:12813029
identification of DAB2IP as a negative regulator of ASK1:14-3-3 interaction
AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation

ASK1*|oligomer@Cytosol

References
rc_re1324( Regulated Cell Death ):
PMID:11689443
in 293T, in Hela, in L929, interaction between ectopically expressed tagged ASK1 and PPP5
in Hela, PPP5 expression inhibits ASK1 activity
in vitro, purified ASK1 dephosphorylated by recombinant PPP5
rc_re1325( Regulated Cell Death ):
PMID:9774977
ASK1 activation by TRAF2 upon TNF
PMID:18292600
in vascular endothelial cell, by DAB2IP
PMID:15310755
DAB2IP
PMID:16252010
rc_re1308( Regulated Cell Death ):
PMID:11920685
no access to the article.
The abstract suggests that ASK1 activation could procede through autophosphorylation

ASK1*|pho|oligomer@Cytosol

References
rc_re1308( Regulated Cell Death ):
PMID:11920685
no access to the article.
The abstract suggests that ASK1 activation could procede through autophosphorylation
rc_re1324( Regulated Cell Death ):
PMID:11689443
in 293T, in Hela, in L929, interaction between ectopically expressed tagged ASK1 and PPP5
in Hela, PPP5 expression inhibits ASK1 activity
in vitro, purified ASK1 dephosphorylated by recombinant PPP5

ASK1*@Cytoplasm

References
s_wnc2_re77:( Survival ) PMID:16648474

ASK1*|pho@Cytoplasm

References
s_wnc2_re77:( Survival ) PMID:16648474

Modifications:
In compartment: Cytoplasm

ASK1*@Cytoplasm
ASK1*|pho@Cytoplasm

In compartment: Cytosol

ASK1*@Cytosol
ASK1*|oligomer@Cytosol
ASK1*|pho|active@Cytosol
ASK1*|pho|oligomer@Cytosol
ASK1*|unk|S967_pho@Cytosol

Participates in complexes:
In compartment: Cytosol

In compartment: Endosome

ASK1*:CFLAR:Caspase8,10*|ubi:DAXX:FADD:FAF1:FASLG:FAS|pal:FLASH*:RIPK1|emp|K377_ubi:TRAF2@Endosome

Participates in reactions:
As Reactant or Product:

As Catalyser: