Protein TSC2 map

Identifiers
HUGO:TSC2
tuberous sclerosis 2
HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815
HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2
P49815

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:12906785 PMID:19022819
AKT activates Rapamycin associated protein FRAP2 ( mTOR ) probably through Tuberin/GTP-binding protein Ras homolog enriched in brain ( RHEB ) pathway.
PMID:17680028
PMID:16636147
PMID:20146692

TSC2|​S664_pho|​M1_unk@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re353:( Regulated Cell Death  map ) PMID:15851026

TSC2|​M1_unk@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re1267( Regulated Cell Death  map ):
reactionType:is.a
logical:re1266_s4082_re1267=FALSE

TSC2|​pho|​M1_unk@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re361( Regulated Cell Death  map ):
PMID:18974095
in HEK293, in vitro
by DAPK1 (DAPK1 phosphorylation status not assessed)

TSC2|​M1_ace@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re1266( Regulated Cell Death  map ):
PMID:20145209
in vitro, in HEK293T, ARD1/NAA10 _alpha_acetylation of TSC2
ARD1 ectopic expression and silencing affects TORC1 activity
relevance to cancer development
rc_re1268:( Regulated Cell Death  map ) reactionType:is.a

TSC2@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re1266( Regulated Cell Death  map ):
PMID:20145209
in vitro, in HEK293T, ARD1/NAA10 _alpha_acetylation of TSC2
ARD1 ectopic expression and silencing affects TORC1 activity
relevance to cancer development
rc_re1267( Regulated Cell Death  map ):
reactionType:is.a
logical:re1266_s4082_re1267=FALSE

TSC2|​ubi@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

TSC2@Cytoplasm

References
su_akt1_s_akt1_re44:( Survival  map ) PMID:16464865
su_akt1_s_akt1_re45( Survival  map ):
PMID:14551205
PMID:17693255

TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane

References
s_akt1_re37( Survival  map ):
PMID:16636147
ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN
s_akt1_re169( Survival  map ):
Phosphorylation of S939 and S981 by Akt initiates binding of 14-3-3 protein to TSC2 leading to trans
su_akt1_s_akt1_re169( Survival  map ):

Modifications:
In compartment: Cytoplasm
  1. TSC2@Cytoplasm map
In compartment: Cytosol
  1. TSC2@Cytosol map
  2. TSC2|​ubi@Cytosol map
  3. TSC2|​M1_ace@Cytosol map
  4. TSC2|​M1_unk@Cytosol map
  5. TSC2|​pho|​M1_unk@Cytosol map
  6. TSC2|​S664_pho|​M1_unk@Cytosol map
In compartment: Endosome Membrane
  1. TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
Participates in complexes:
In compartment: Cytoplasm
  1. E3*:​TSC2@Cytoplasm map
  2. PAM*:​TSC2@Cytoplasm map
  3. HERC1:​TSC2@Cytoplasm map
  4. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Cytoplasm map
  5. CUL4*:​DCAF*:​FBW5*:​RBX1:​TSC2@Cytoplasm map
In compartment: Cytosol
  1. TSC1:​TSC2|​M1_unk@Cytosol map
  2. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol map
  3. TSC1:​TSC2|​S1798_pho|​M1_unk@Cytosol map
  4. TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol map
  5. TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytosol map
  6. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytosol map
  7. TSC1:​TSC2|​don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytosol map
  8. 14-3-3*|​unk:​TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol map
In compartment: Endosome Membrane
  1. TSC1:​TSC2@Endosome Membrane map
  2. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  3. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TSC1:​TSC2@INNATE_IMMUNE_CELL_Cytosol map
  2. TSC1:​TSC2|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Lysosome
  1. TSC1:​TSC2@Lysosome map
  2. TSC1:​TSC2|​S939_pho@Lysosome map
In compartment: T_cell
  1. TSC1:​TSC2@T_cell map
  2. TSC1:​TSC2|​pho@T_cell map
Participates in reactions:
As Reactant or Product:
  1. TSC1:​TSC2@T_cell map → map TSC1:​TSC2|​pho@T_cell map
  2. TSC1:​TSC2@INNATE_IMMUNE_CELL_Cytosol map → map TSC1:​TSC2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. TSC1:​TSC2@Lysosome map → map TSC1:​TSC2|​S939_pho@Lysosome map
  4. rTSC2@Nucleus map → map TSC2@Cytosol map
  5. TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol map → map TSC1:​TSC2|​M1_unk@Cytosol map
  6. TSC2@Cytosol map → map TSC2|​M1_ace@Cytosol map
  7. TSC2@Cytosol map → map TSC2|​M1_unk@Cytosol map
  8. TSC2|​M1_ace@Cytosol map → map TSC2|​M1_unk@Cytosol map
  9. TSC2@Cytosol map → map TSC2|​ubi@Cytosol map
  10. TSC2|​ubi@Cytosol map → map degraded
  11. TSC1:​TSC2|​M1_unk@Cytosol map → map TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol map
  12. TSC1:​TSC2|​M1_unk@Cytosol map → map TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol map
  13. TSC1:​TSC2|​M1_unk@Cytosol map → map TSC1@Cytosol map + TSC2|​S664_pho|​M1_unk@Cytosol map
  14. 14-3-3*|​unk@Cytosol map + TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol map → map 14-3-3*|​unk:​TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol map
  15. TSC1:​TSC2|​M1_unk@Cytosol map → map TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytosol map
  16. TSC1:​TSC2|​M1_unk@Cytosol map → map TSC1:​TSC2|​S1798_pho|​M1_unk@Cytosol map
  17. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol map → map TSC1:​TSC2|​don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytosol map
  18. TSC1:​TSC2|​M1_unk@Cytosol map → map TSC1:​TSC2|​don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytosol map
  19. TSC2|​M1_unk@Cytosol map + TSC1@Cytosol map → map TSC1:​TSC2|​M1_unk@Cytosol map
  20. TSC1:​TSC2|​M1_unk@Cytosol map → map TSC1@Cytosol map + TSC2|​pho|​M1_unk@Cytosol map
  21. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol map → map TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytosol map
  22. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytosol map → map TSC1:​TSC2|​don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytosol map
  23. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map → map 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Cytoplasm map
  24. TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map + 14-3-3*@Cytoplasm map → map 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  25. HERC1:​TSC2@Cytoplasm map → map Ubiquitination@Cytoplasm map
  26. PAM*:​TSC2@Cytoplasm map → map Ubiquitination@Cytoplasm map
  27. E3*:​TSC2@Cytoplasm map → map Ubiquitination@Cytoplasm map
  28. CUL4*:​DCAF*:​FBW5*:​RBX1:​TSC2@Cytoplasm map → map Ubiquitination@Cytoplasm map
  29. TSC1:​TSC2@Endosome Membrane map → map TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  30. HERC1:​TSC2@Cytoplasm map → map HERC1@Cytoplasm map + TSC2@Cytoplasm map
  31. TSC1@Endosome Membrane map + TSC2@Cytoplasm map → map TSC1:​TSC2@Endosome Membrane map
  32. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map → map TSC1@Endosome Membrane map + TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  33. TSC2@Cytosol map + TSC1@Cytosol map → map su_shh1_s_shh3_s120
As Catalyser:
  1. (GTP:​RHEB)|​active@T_cell map + GDP@T_cell map → map GDP:​RHEB@T_cell map + GTP@T_cell map
  2. (GTP:​RHEB)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map → map GDP:​RHEB@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map
  3. GTP:​RHEB@Lysosome map → map GDP:​RHEB@Lysosome map
  4. rc_s2052 → map rc_s2054
  5. RHEB|​pho@Endosome Membrane map → map RHEB@Endosome Membrane map
  6. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map + 14-3-3*@Cytoplasm map → map 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map