Protein FOXO* map

Identifiers
HUGO:FOXO1 HUGO:FOXO3
HUGO:FOXO1 HUGO:FOXO3 HUGO:FOXO4 HUGO:FOXO6
forkhead box O1
HUGO:FOXO1, HGNC:3819, ENTREZ:2308, UNIPROT:Q12778
forkhead box O3
HUGO:FOXO3, HGNC:3821, ENTREZ:2309, UNIPROT:O43524

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / SENESCENCE  map
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G1_S_CHECKPOINT  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
PMID:21708191, PMID:21613825, PMID:11154281, PMID:17940099, PMID:19380174, PMID:15084260
PMID:23301705

FOXO*|​pho@Cytosol

References
mo_re38:( motility  map ) PMID:18471976 PMID:19945467 PMID:27328425

FOXO*@Cytosol

References
mo_re38:( motility  map ) PMID:18471976 PMID:19945467 PMID:27328425

FOXO*@Nucleus

References
mo_re39:( motility  map ) PMID:19945467 PMID:27328425
mo_re40:( motility  map ) PMID:18471976 PMID:19945467 PMID:27328425
mo_re41:( motility  map ) PMID:18471976 PMID:27328425

FOXO*|​unk@Nucleus

References
ce_re415:( Cell Cycle DNA Repair  map ) PMID:17038621, PMID:15677884
ce_re344:( Cell Cycle DNA Repair  map ) CHECKPOINT is p53_dependent_G1S_checkpoint
ce_re399( Cell Cycle DNA Repair  map ):
Repression of p15INK4b expression by Myc through association with Miz-1:
PMID:9308237, PMID:11283613
Repression of pINK expression by BMI1:
PMID:17936558

FOXO*|​pho|​pho@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re331( Regulated Cell Death  map ):
PMID:10102273
in vitro, by Akt, phosphosites identified by mutagenesis
in 293T using phosphoFOXO1 antibodies
PMID:18593906
in HEK293T, by PIM1s isoform, FOXO3 phosphorylated and inactivated. Phosphomutant of FOXO3 is not phosphorylated and the expression of a reporter gene is not inhibited.
rc_re333:( Regulated Cell Death  map ) logical:re333_s2093=FALSE

Modifications:
In compartment: Cytosol
  1. FOXO*@Cytosol map
  2. FOXO*|​pho@Cytosol map
  3. FOXO*|​pho|​pho@Cytosol map
In compartment: Nucleus
  1. FOXO*@Nucleus map
  2. FOXO*|​unk@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. 14-3-3*|​unk:​FOXO*|​pho|​pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. FOXO*@Nucleus map → map FOXO*|​unk@Nucleus map
  2. FOXO*|​unk@Nucleus map → map FOXO*@Nucleus map
  3. FOXO*@Nucleus map → map FOXO3@Nucleus map
  4. FOXO*@Nucleus map → map FOXO1@Nucleus map
  5. FOXO*@Nucleus map → map FOXO4@Nucleus map
  6. FOXO*@Nucleus map → map FOXO6@Nucleus map
  7. rFOXO*@Nucleus map → map FOXO*@Nucleus map
  8. FOXO*@Cytosol map → map FOXO*|​pho@Cytosol map
  9. FOXO*@Cytosol map → map FOXO*@Nucleus map
  10. rc_s1459 → map FOXO*@Nucleus map
  11. FOXO3@Cytosol map → map FOXO*@Cytosol map
  12. FOXO*@Cytosol map → map FOXO*|​pho|​pho@Cytosol map
  13. FOXO*|​pho|​pho@Cytosol map → map FOXO*@Cytosol map
  14. 14-3-3*|​unk@Cytosol map + FOXO*|​pho|​pho@Cytosol map → map 14-3-3*|​unk:​FOXO*|​pho|​pho@Cytosol map
  15. FOXO1:​PPARGC1A@Nucleus map → map FOXO*@Nucleus map
  16. FOXO1@Cytosol map → map FOXO*@Cytosol map
  17. FOXO*@Cytosol map → map FOXO*@Nucleus map
  18. FOXO3@Nucleus map → map FOXO*@Nucleus map
  19. FOXO1@Nucleus map → map FOXO*@Nucleus map
As Catalyser:
  1. gCIP/KIP*@Nucleus map → map rCIP/KIP*@Nucleus map
  2. gINK4*@Nucleus map → map rINK4*@Nucleus map
  3. gp21CIP1*@Nucleus map → map rp21CIP1*@Nucleus map
  4. gp27KIP1*@Nucleus map → map rp27KIP1*@Nucleus map
  5. gCyclinG2*@Nucleus map → map rCyclinG2*@Nucleus map
  6. gPMAIP1@Nucleus map → map rPMAIP1@Nucleus map
  7. gBIRC5@Nucleus map → map rBIRC5@Nucleus map
  8. gBCL2L11@Nucleus map → map rBCL2L11@Nucleus map
  9. gATG12@Nucleus map → map rATG12@Nucleus map
  10. gGABARAPL1@Nucleus map → map rGABARAPL1@Nucleus map
  11. gBNIP3@Nucleus map → map rBNIP3@Nucleus map
  12. gSOD2@Nucleus map → map rSOD2@Nucleus map
  13. gFASL*@Nucleus map → map rFASL*@Nucleus map
  14. gCITED2@Nucleus map → map rCITED2@Nucleus map
  15. gp27KIP1*@Nucleus map → map rp27KIP1*@Nucleus map
  16. gIGFBP1@Nucleus map → map rIGFBP1@Nucleus map