1. TSC1
2. TSC2

Identifiers
NAME:TSC1:TSC2

References
PMID:12906785 PMID:19022819

Identifiers
NAME:TSC1:TSC2

References
PMID:12906785 PMID:19022819

Identifiers
NAME:TSC1:TSC2

References
PMID:23030059
rc_re352( Regulated Cell Death  ):
PMID:14651849
PMID:19339977
review
PMID:18692468
SESN2 promotes TSC2 phosphorylation, and interacts with both AMPK and TSC2.
rc_re357:( Regulated Cell Death  ) reactionType:is.a
rc_re363( Regulated Cell Death  ):
PMID:16959574
in different murine cell lines, inhibited upon Wnt signalling
in HEK293

Identifiers
NAME:TSC1:TSC2

Identifiers
NAME:TSC1:TSC2

References
s_akt1_re45( Survival  ):
PMID:14551205
PMID:17693255
s_akt1_re37( Survival  ):
PMID:16636147
ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN
s_akt1_re61:( Survival  ) PMID:17604271

Identifiers
NAME:TSC1:TSC2

References
mo_re177:( motility  ) PMID:26597054 PMID:27328425

Identifiers
NAME:TSC1:TSC2

References
mo_re177:( motility  ) PMID:26597054 PMID:27328425

Identifiers
NAME:TSC1:TSC2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 

References
CASCADE:IL15
CASCADE:CSF2
PMID:12906785, PMID:19022819
AKT activates Rapamycin associated protein FRAP2 ( mTOR ) probably through Tuberin/GTP-binding protein Ras homolog enriched in brain ( RHEB ) pathway.

Identifiers
NAME:TSC1:TSC2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 

References
CASCADE:IL15
PMID:12906785, PMID:19022819
AKT activates Rapamycin associated protein FRAP2 ( mTOR ) probably through Tuberin/GTP-binding protein Ras homolog enriched in brain ( RHEB ) pathway.

Identifiers
NAME:TSC1:TSC2

References
rc_re357:( Regulated Cell Death  ) reactionType:is.a
rc_re359( Regulated Cell Death  ):
reactionType:is.a
inferred from re259 and re260
rc_re365( Regulated Cell Death  ):
PMID:19339977
review
PMID:12869586
PMID:12906785

Identifiers
NAME:TSC1:TSC2

References
rc_re356:( Regulated Cell Death  ) PMID:15342917

Identifiers
NAME:TSC1:TSC2

References
rc_re363( Regulated Cell Death  ):
PMID:16959574
in different murine cell lines, inhibited upon Wnt signalling
in HEK293

Identifiers
NAME:TSC1:TSC2

References
rc_re351( Regulated Cell Death  ):
PMID:12150915
in NIH3T3
in HEK293
PMID:12172553
rc_re352( Regulated Cell Death  ):
PMID:14651849
PMID:19339977
review
PMID:18692468
SESN2 promotes TSC2 phosphorylation, and interacts with both AMPK and TSC2.
rc_re353:( Regulated Cell Death  ) PMID:15851026
rc_re355:( Regulated Cell Death  ) PMID:17693255
rc_re356:( Regulated Cell Death  ) PMID:15342917
rc_re359( Regulated Cell Death  ):
reactionType:is.a
inferred from re259 and re260
rc_re361( Regulated Cell Death  ):
PMID:18974095
in HEK293, in vitro
by DAPK1 (DAPK1 phosphorylation status not assessed)

Identifiers
NAME:TSC1:TSC2

References
rc_re351( Regulated Cell Death  ):
PMID:12150915
in NIH3T3
in HEK293
PMID:12172553
rc_re354( Regulated Cell Death  ):
logical:re354_s2093=FALSE
PMID:18198340
DDIT4 mediated hypoxic signalling to mTPMID:12468542
14-3-3_beta_ forms a ternary complex with TSC1 and Akt-phosphorylated TSC2

Identifiers
NAME:TSC1:TSC2

References
rc_re355:( Regulated Cell Death  ) PMID:17693255

1. TSC1:​TSC2|​M1_unk@Cytosol
2. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol
3. TSC1:​TSC2|​S1798_pho|​M1_unk@Cytosol
4. TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol
5. TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytosol
6. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytosol
7. TSC1:​TSC2|​don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytosol

1. TSC1:​TSC2@Endosome Membrane
2. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane

1. TSC1:​TSC2@INNATE_IMMUNE_CELL_Cytosol
2. TSC1:​TSC2|​pho@INNATE_IMMUNE_CELL_Cytosol

1. TSC1:​TSC2@Lysosome
2. TSC1:​TSC2|​S939_pho@Lysosome

1. TSC1:​TSC2@T_cell
2. TSC1:​TSC2|​pho@T_cell

1. TSC1:​TSC2@T_cell → TSC1:​TSC2|​pho@T_cell
2. TSC1:​TSC2@INNATE_IMMUNE_CELL_Cytosol → TSC1:​TSC2|​pho@INNATE_IMMUNE_CELL_Cytosol
3. TSC1:​TSC2@Lysosome → TSC1:​TSC2|​S939_pho@Lysosome
4. TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol → TSC1:​TSC2|​M1_unk@Cytosol
5. TSC1:​TSC2|​M1_unk@Cytosol → TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol
6. TSC1:​TSC2|​M1_unk@Cytosol → TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol
7. TSC1:​TSC2|​M1_unk@Cytosol → TSC1@Cytosol + TSC2|​S664_pho|​M1_unk@Cytosol
8. 14-3-3*|​unk@Cytosol + TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol → 14-3-3*|​unk:​TSC1:​TSC2|​pho|​T1462_pho|​M1_unk@Cytosol
9. TSC1:​TSC2|​M1_unk@Cytosol → TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytosol
10. TSC1:​TSC2|​M1_unk@Cytosol → TSC1:​TSC2|​S1798_pho|​M1_unk@Cytosol
11. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol → TSC1:​TSC2|​don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytosol
12. TSC1:​TSC2|​M1_unk@Cytosol → TSC1:​TSC2|​don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytosol
13. TSC2|​M1_unk@Cytosol + TSC1@Cytosol → TSC1:​TSC2|​M1_unk@Cytosol
14. TSC1:​TSC2|​M1_unk@Cytosol → TSC1@Cytosol + TSC2|​pho|​M1_unk@Cytosol
15. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol → TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytosol
16. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytosol → TSC1:​TSC2|​don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytosol
17. TSC1:​TSC2@Endosome Membrane → TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane
18. TSC1@Endosome Membrane + TSC2@Cytoplasm → TSC1:​TSC2@Endosome Membrane
19. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane → TSC1@Endosome Membrane + TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane

1. (GTP:​RHEB)|​active@T_cell + GDP@T_cell → GDP:​RHEB@T_cell + GTP@T_cell
2. (GTP:​RHEB)|​active@INNATE_IMMUNE_CELL_Cytosol + GDP@INNATE_IMMUNE_CELL_Cytosol → GDP:​RHEB@INNATE_IMMUNE_CELL_Cytosol + GTP@INNATE_IMMUNE_CELL_Cytosol
3. GTP:​RHEB@Lysosome → GDP:​RHEB@Lysosome
4. rc_s2052 → rc_s2054
5. RHEB|​pho@Endosome Membrane → RHEB@Endosome Membrane
6. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome + 14-3-3*@Cytoplasm → 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome