Identifiers
forkhead box O3
HUGO:FOXO3, HGNC:3821, ENTREZ:2309, GENECARDS:GC06P108881, UNIPROT:O43524????
HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524
FKHRL1 FOXO3A
HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / PI3K_AKT_MTOR
References
PMID:19564415
The transcription factor FOXO3, negatively regulated by binding to 14-3-3 protein family, induces MMP9 and MMP13 expression.
This explains the role of FOXO3 in promoting tumor invasion.
PMID:16288288
PMID:17646672
References
em_emtc_emtc_re65( EMT Senescence ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:16079281
MMP-9 transcription is activated in response to Snail expression
Oncogenic H-Ras (RasV12) synergistically co-operates with Snail in the induction of MMP-9 transcription and expression.
Phosphorylated Sp-1 is recruited to the MMP-9 promoter following activation of the Erk1/2 pathway
PMID:19564415
The transcription factor FOXO3, negatively regulated by binding to 14-3-3 protein family, induces MMP9 and MMP13 expression.
This explains the role of FOXO3 in promoting tumor invasion.
PMID:22439866
c-Myb strongly increased the expression/activity of cathepsin D and matrix metalloproteinase (MMP) 9 and significantly downregulated MMP1.
PMID:8844971
Molecular mechanism of transcriptional activation of human gelatinase B (=MMP9) by proximal promoter. (NFKB)
PMID:16556862
ROS regulate MMP gene expression and activation of proenzymes. MMP-1, MMP-2, MMP-7, and MMP-9 are activated by ROS through interactions with thiol groups
References
su_mpk1_mpk1_re262( Survival ):
JNK phosphorylates MST1 at serine 82 which leads to the enhancement of MST1 activation. The activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death.
Phosphorylation of FOXO3 by Akt creates a binding site for the 14-3-3 family of proteins. The complex of FOXO3 and 14-3-3 is retained in the cytosol blocking transcription of genes normally stimulated by FOXO3.
PMID:20028971 PMID:12040186
References
s_akt1_re101:( Survival ) PMID:11154281
References
s_akt1_re103:( Survival ) PMID:11154281
References
s_akt2_re8:( Survival ) PMID:11864996
References
s_akt2_re75:( Survival ) PMID:19321440
References
s_akt2_re75:( Survival ) PMID:19321440
References
s_akt2_re82:( Survival ) PMID15084260
s_akt2_re83:( Survival ) PMID:15084260
References
s_akt2_re83:( Survival ) PMID:15084260
References
s_akt2_re127:( Survival ) PMID:15084260
+ FOXO3@Nucleus → 14-3-3*:FOXO3@Nucleus
→ FOXO3|pho@Nucleus
→ FOXO3@Nucleus
→ FOXO3@Cytosol
+ RUNX3@Nucleus → rc_s1459
→ FOXO*@Cytosol
→ FOXO*@Nucleus
→ FOXO3|S315_pho@Nucleus
→ FOXO3|T32_pho|S253_pho|S315_pho@Nucleus
+ 14-3-3*@Cytoplasm → su_akt1_s_akt1_s479
14-3-3*:FOXO3|T32_pho|S253_pho|S315_pho@Cytoplasm
→ FOXO3|S644_pho|ubi@Cytoplasm
FOXO3|pho:promoter_region@Nucleus
→ FOXO3|pho|pho|pho:promoter_region@Nucleus
→ FOXO3|pho|pho|pho@Nucleus + gpromoter_region@Nucleus
→ 14-3-3*@Cytoplasm + FOXO3|pho|pho|pho@Cytoplasm
→ FOXO3|pho|pho|pho|ubi@Cytoplasm
+ 14-3-3*@Nucleus → su_akt1_s_akt2_s25
FOXO3|S644_pho:promoter_region@Nucleus
→ FOXO3|S644_pho@Nucleus + gpromoter_region@Nucleus
→ FOXO3|S644_pho@Cytoplasm
14-3-3*:FOXO3|pho|pho|pho@Cytoplasm
→ FOXO3|pho@Nucleus
→ Apoptosis@Cytoplasm