Identifiers
HUGO:CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
HUGO:CDKN1B, HGNC:1785, ENTREZ:1027, GENECARDS:GC12P012867, UNIPROT:P46527??
HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527
HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / SENESCENCE 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / RCD_GENES 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / PI3K_AKT_MTOR 

References
PMID:24954210
p27, p16 and p15 inhibits CDK4_6. This induces a G1 cell cycle arrest.
PMID:18636226
PMID:19887899

References
mo_re43:( motility  ) PMID:18471976

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / RCD_GENES 

References
rc_re1132:( Regulated Cell Death  ) PMID:18593906
rc_re1133( Regulated Cell Death  ):
PMID:18593906
in HEK293T with transfected proteins

References
s_akt1_re96( Survival  ):
PMID:18570873
PMID:18636226
p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase

References
s_akt1_re96( Survival  ):
PMID:18570873
PMID:18636226
p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase
s_akt1_re97:( Survival  ) PMID:19887899

References
s_akt2_re38( Survival  ):
PMID:18636226
PMID:15147722
PMID:14536078
PMID:12459251
s_akt2_re39:( Survival  ) PMID:15147722 PMID:18006823

References
s_akt2_re39:( Survival  ) PMID:15147722 PMID:18006823

References
s_akt2_re45:( Survival  ) PMID:18636226
s_akt2_re46:( Survival  ) PMID:15531880

References
s_akt2_re48:( Survival  ) PMID:15147722

References
s_akt2_re46:( Survival  ) PMID:15531880

References
s_akt2_re137:( Survival  ) PMID:11124803
s_akt2_re140:( Survival  ) PMID:18006823

References
s_akt2_re140:( Survival  ) PMID:18006823

1. p27KIP1*@Cytoplasm
2. p27KIP1*@Cytoplasm
3. p27KIP1*|​pho@Cytoplasm
4. p27KIP1*|​S10_pho@Cytoplasm
5. p27KIP1*|​pho|​ubi|​ubi|​ubi@Cytoplasm
6. p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm
7. p27KIP1*|​pho|​pho|​emp|​ubi|​ubi|​ubi@Cytoplasm

1. p27KIP1*@Cytosol
2. p27KIP1*|​pho@Cytosol

1. p27KIP1*@Nucleus
2. p27KIP1*|​pho@Nucleus
3. p27KIP1*|​pho|​pho@Nucleus
4. p27KIP1*|​T198_pho|​T157_pho@Nucleus
5. p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus
6. p27KIP1*|​pho|​pho|​ubi|​pho|​S157_pho@Nucleus

1. CRM1*:​p27KIP1*|​pho@Cytoplasm
2. 14-3-3*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm
3. CDK4_6*:​CyclinD*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm
4. CDK4_6*:​CyclinD*:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Cytoplasm

1. CDK2:​p27KIP1*@Cytosol
2. 14-3-3*|​unk:​p27KIP1*|​T198_pho|​T157_pho@Cytosol
3. CDK4_6*:​CyclinD1*:​p27KIP1*@Cytosol

1. CRM1*:​p27KIP1*|​pho@Nucleus
2. CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus
3. CDK2:​MYC:​p27KIP1*@Nucleus

1. p27KIP1*@Cytosol → p27KIP1*|​pho@Cytosol
2. p27KIP1*|​pho@Cytosol → degraded
3. rp27KIP1*@Nucleus → p27KIP1*@Cytosol
4. CDK4_6*:​CyclinD1*@Cytosol + p27KIP1*@Cytosol → CDK4_6*:​CyclinD1*:​p27KIP1*@Cytosol
5. p27KIP1*@Cytosol + CDK2@Cytosol → CDK2:​p27KIP1*@Cytosol
6. CDK2:​p27KIP1*@Cytosol + MYC@Nucleus → CDK2:​MYC:​p27KIP1*@Nucleus
7. rp27KIP1*@Nucleus → p27KIP1*@Nucleus
8. p27KIP1*@Nucleus → G1 Cell cycle arrest@Nucleus
9. p27KIP1*@Nucleus → p27KIP1*|​T198_pho|​T157_pho@Nucleus
10. 14-3-3*|​unk@Cytosol + p27KIP1*|​T198_pho|​T157_pho@Nucleus → 14-3-3*|​unk:​p27KIP1*|​T198_pho|​T157_pho@Cytosol
11. rp27KIP1*@Nucleus → p27KIP1*@Nucleus
12. rp27KIP1*@Nucleus → p27KIP1*@Cytoplasm
13. CDK4_6*:​CyclinD*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm → su_akt1_s_akt1_s736
14. p27KIP1*|​S10_pho@Cytoplasm → p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm
15. p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm + 14-3-3*@Cytoplasm → 14-3-3*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm
16. CDK4_6*@Cytoplasm + p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm + CyclinD*@Cytoplasm → CDK4_6*:​CyclinD*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm
17. su_akt1_s_akt2_s120 → CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus
18. CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus → CyclinD*|​T286_pho@Nucleus + p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus + CDK4_6*@Nucleus
19. p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus → p27KIP1*|​pho|​pho|​ubi|​pho|​S157_pho@Nucleus
20. rp27KIP1*@Nucleus → p27KIP1*@Cytoplasm
21. p27KIP1*@Nucleus → p27KIP1*|​pho@Nucleus
22. p27KIP1*|​pho@Nucleus → p27KIP1*|​pho|​pho@Nucleus
23. p27KIP1*|​pho|​pho@Nucleus → G0 phase@Nucleus
24. ce_s3119 + CDK2@Nucleus + p27KIP1*|​pho@Nucleus → su_akt1_s_akt2_s96
25. su_akt1_s_akt2_s96 → su_akt1_s_akt2_s95 + p27KIP1*|​pho@Nucleus
26. p27KIP1*|​pho@Nucleus → p27KIP1*|​pho|​pho@Nucleus
27. p27KIP1*|​pho@Nucleus + CRM1*@Nucleus → CRM1*:​p27KIP1*|​pho@Nucleus
28. CRM1*:​p27KIP1*|​pho@Nucleus → CRM1*:​p27KIP1*|​pho@Cytoplasm
29. CRM1*:​p27KIP1*|​pho@Cytoplasm → CRM1*@Cytoplasm + p27KIP1*|​pho@Cytoplasm
30. p27KIP1*|​pho@Cytoplasm → p27KIP1*|​pho|​ubi|​ubi|​ubi@Cytoplasm
31. p27KIP1*|​pho|​pho@Nucleus → p27KIP1*|​pho|​pho|​emp|​ubi|​ubi|​ubi@Cytoplasm
32. p27KIP1*@Cytoplasm → p27KIP1*@Nucleus
33. CDK4_6*:​CyclinD*:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Cytoplasm → su_akt1_s_akt2_s120
34. rCyclinD*@Nucleus → CDK4_6*:​CyclinD*:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Cytoplasm

1. gBMI1@Nucleus → rBMI1@Nucleus
2. gCDKN2A@Nucleus → rp16INK4A*@Nucleus
3. gp21CIP1*@Nucleus → rp21CIP1*@Nucleus
4. gTERT@Nucleus → rTERT@Nucleus
5. E2F1@Nucleus → E2F1@Nucleus