Identifiers
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HUGO:YWHAB, HGNC:12849, ENTREZ:7529, GENECARDS:GC20P043515, UNIPROT:P31946??
HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946
"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide", YWHAA
HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_NON_CANONICAL
References
YWHAB is so-called 14-3-3 alpha/beta
PMID:9069260
References
em_emtc_emtc_re386( EMT Senescence ):
PMID:9069260
Activated HRAS (GTP bound forn) is associated with the plasma membrane.
Inactive RAF1 is associated in the cytoplasm with YWHAB via S259 phosphorylation site and also binding site.
RAF1 has a RAS-binding Cysteine-rich domain (CRD) and an additional RAS-binding domain (RBD).
RAF1 binds activated HRAS via the RBD. This binding displaces YWHAB from Ser259 and unmasks the CRD.
YWHAB has been displaced from S259 may now bind its higher affinity S621 site.
This stabilises an OPEN RAF1 conformation that is catalytically active.
Active and open RAF1 binds to RAS via both CRD and RBD domains.
References
s_wnc1_re94:( Survival ) PMID:21262972
→ YWHAB@Cytosol
→ YWHAB@Cytosol
+ YWHAB@Cytosol → RAF1|S259_pho|S621_pho|S_pho|closed:YWHAB@Cytosol
+ em_emtc_emtc_s3009 → HRAS:RAF1|S259_pho|S621_pho|S_pho|closed:YWHAB@Cytosol
+ YWHAB@Cytosol → HRAS:RAF1|S259_pho|S621_pho|S_pho|open:YWHAB@Cytosol
+ ATP@Cytosol → RAF1|S259_pho|S621_pho|Y340_pho|Y341_pho|open@Cytosol + ADP@Cytosol
→ 14-3-3*@Cytosol
+ DACT1|S237_pho|S827_pho@Cytoplasm → DACT1|S237_pho|S827_pho:YWHAB@Cytoplasm