CDK1:CyclinB1*

Complex CDK1:CyclinB1*

Complex composition:

CDK1|T161_pho|pho:CyclinB1*@Nucleus

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_CC_PHASE
Cell Cycle DNA Repair / M_CC_PHASE

CDK1|T161_pho:CyclinB1*@Nucleus

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_M_CHECKPOINT

CDK1|T161_pho:CyclinB1*@Nucleus

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_CC_PHASE
Cell Cycle DNA Repair / M_CC_PHASE

References
ce_re120( Cell Cycle DNA Repair ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
ce_re313( Cell Cycle DNA Repair ):
Activation by PLK phosphorylation at S191, S198
Activation by CDC2 phosphorylation at S214
PMID:17596790
ce_re383:( Cell Cycle DNA Repair ) PMID:9892021

CDK1|Y14/15_pho|T161_pho:CyclinB1*@Nucleus

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_CC_PHASE
Cell Cycle DNA Repair / M_CC_PHASE

References
ce_re305:( Cell Cycle DNA Repair ) CAK phosphorylation of CDC2 is the first step toward complex activation

CDK1:CyclinB1*@Nucleus

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_CC_PHASE
Cell Cycle DNA Repair / M_CC_PHASE

References
ce_re273:( Cell Cycle DNA Repair ) Wee1 phosphorylation of CDC2 keeps the complex inactive

CDK1|Y14/15_pho:CyclinB1*@Nucleus

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_CC_PHASE
Cell Cycle DNA Repair / M_CC_PHASE

References
ce_re273:( Cell Cycle DNA Repair ) Wee1 phosphorylation of CDC2 keeps the complex inactive
ce_re305:( Cell Cycle DNA Repair ) CAK phosphorylation of CDC2 is the first step toward complex activation

CDK1:CyclinB1*@Cytosol

Identifiers
NAME:CDK1:CyclinB1*

References
rc_re498( Regulated Cell Death ):
PMID:12792650
Direct phosphorylation of CASP9 by ERK2 sufficient to block CASP9 processing
in vitro, recombinant hCASP9 phosphorylated on T125 by cytosolic extract or ERK2
in Hela cells, interaction GST-CASP9 / ERK
in Hela or HEK293, CASP9 T125 phosphorylation by OA, consititutively active MEK1, EGF or TPA
PMID:17466630
CASP9 T125 phosphorylation by CCNB1:CDC2
comment: phosphorylation during mitosis, when nuclear envelope is broken down
PMID:19081073
CASP9 T125 phosphorylation by DYRK1A
PMID:19016842
PMID:19586613
CASP9 T125 phosphorylation by DYRK1A and p38
rc_re669:( Regulated Cell Death ) PMID:11069302

Modifications:
Participates in complexes:
In compartment: Cytosol

CDK1:CyclinB1*@Cytosol

In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: