Protein GLI2-185* map

Identifiers
Gli family zinc finger 2
HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

References
Glioma-associated oncogene family zinc finger
PMID:18497536 PMID:17845852 PMID:11001584

GLI2-185*@Cytosol

References
s_shh1_re36( Survival  map ):
PMID:20956384
PMID:19592253
PMID:0643644
s_shh1_re68:( Survival  map ) PMID:18455992

GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi@Cytosol

References
s_shh1_re63( Survival  map ):
PMID:16611981
Proteolytic degradation is very inefficient therefore more ful-length Gli2 present

GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi@Proteosome

References
s_shh1_re63( Survival  map ):
PMID:16611981
Proteolytic degradation is very inefficient therefore more ful-length Gli2 present
s_shh1_re11( Survival  map ):
PMID:17283082
PMID:19147008
GLI2 ompletely degraded no truncated form present
Truncated form of GLI2 is produced
su_shh1_s_shh1_re11( Survival  map ):

GLI2-185*@Primary Cilium

References
s_shh1_re40( Survival  map ):
PMID:20956384
PMID:20643644
s_shh1_re45( Survival  map ):
PMID:19878745
su_shh1_s_shh1_re45( Survival  map ):

GLI2-185*|​pho|​active@Primary Cilium

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

References
PMID:19878745
Ulk3 phosphorylates Gli2 but not know on which residue
s_shh1_re45( Survival  map ):
PMID:20643644
s_shh1_re76( Survival  map ):
PMID:20711444
PTM=sumoylation N/A in CellDesigner.
Sumoylation not detected on endogenous Gli proteins.
PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact
su_shh1_s_shh1_re45( Survival  map ):

GLI2-185*|​S805_unk|​pho|​active@Primary Cilium

References
s_shh1_re76( Survival  map ):
PMID:20711444
PTM=sumoylation N/A in CellDesigner.
Sumoylation not detected on endogenous Gli proteins.
PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact
s_shh1_re53:( Survival  map ) PMID:19996169

GLI2-185*|​S805_unk|​pho|​active@Nucleus

References
s_shh1_re53:( Survival  map ) PMID:19996169

GLI2-185*|​pho|​unk|​S956_pho|​active@Nucleus

References
s_shh2_re63:( Survival  map ) PMID:19996099

GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus

References
s_shh2_re72:( Survival  map ) PMID:20081843
s_shh2_re63:( Survival  map ) PMID:19996099
s_shh2_re115:( Survival  map ) PMID:20463034

GLI2-185*|​pho|​unk|​S956_emp|​K757_ace|​active@Nucleus

References
s_shh2_re71:( Survival  map ) PMID:20081843

GLI2-185*|​ubi|​ubi|​pho|​unk|​S956_emp|​active@Nucleus

References
s_shh2_re115:( Survival  map ) PMID:20463034

Modifications:
In compartment: Cytosol
  1. GLI2-185*@Cytosol map
  2. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho@Cytosol map
  3. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi@Cytosol map
In compartment: Nucleus
  1. GLI2-185*|​S805_unk|​pho|​active@Nucleus map
  2. GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus map
  3. GLI2-185*|​pho|​unk|​S956_pho|​active@Nucleus map
  4. GLI2-185*|​pho|​unk|​S956_emp|​K757_ace|​active@Nucleus map
  5. GLI2-185*|​ubi|​ubi|​pho|​unk|​S956_emp|​active@Nucleus map
In compartment: Primary Cilium
  1. GLI2-185*@Primary Cilium map
  2. GLI2-185*|​pho|​active@Primary Cilium map
  3. GLI2-185*|​S805_unk|​pho|​active@Primary Cilium map
In compartment: Proteosome
  1. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi@Proteosome map
Participates in complexes:
In compartment: Cytosol
  1. GLI2-185*:​SUFU:​ULK3@Cytosol map
  2. GLI2-185*|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map
  3. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho:​SUFU:​ULK3@Cytosol map
  4. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map
  5. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map
  6. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho:​SUFU:​ULK3@Cytosol map
  7. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi:​SUFU:​ULK3@Cytosol map
  8. GLI2-185*:​KIF7:​SUFU:​ULK3@Cytosol map
In compartment: Nucleus
  1. GLI2-185*|​pho:​promoter_region@Nucleus map
In compartment: Primary Cilium
  1. GLI2-185*:​KIF7:​SUFU:​ULK3@Primary Cilium map
Participates in reactions:
As Reactant or Product:
  1. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map → map SUFU@Cytosol map + ULK3@Cytosol map + GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho@Cytosol map
  2. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi@Proteosome map → map GLI2-78_sub_TRUNC_endsub_*@Cytosol map
  3. SUFU@Cytosol map + GLI2-185*@Cytosol map + KIF7@Cytosol map + ULK3@Cytosol map → map GLI2-185*:​KIF7:​SUFU:​ULK3@Cytosol map
  4. GLI2-185*:​KIF7:​SUFU:​ULK3@Cytosol map → map GLI2-185*:​KIF7:​SUFU:​ULK3@Primary Cilium map
  5. GLI2-185*:​KIF7:​SUFU:​ULK3@Primary Cilium map → map SUFU@Primary Cilium map + GLI2-185*@Primary Cilium map + KIF7@Primary Cilium map + ULK3@Primary Cilium map
  6. GLI2-185*@Primary Cilium map → map GLI2-185*|​pho|​active@Primary Cilium map
  7. GLI2-185*|​S805_unk|​pho|​active@Primary Cilium map → map GLI2-185*|​S805_unk|​pho|​active@Nucleus map
  8. GLI2-185*:​SUFU:​ULK3@Cytosol map → map GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho:​SUFU:​ULK3@Cytosol map
  9. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho:​SUFU:​ULK3@Cytosol map → map GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho:​SUFU:​ULK3@Cytosol map
  10. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi:​SUFU:​ULK3@Cytosol map → map SUFU@Cytosol map + ULK3@Cytosol map + GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi@Cytosol map
  11. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi@Cytosol map → map GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi@Proteosome map
  12. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho:​SUFU:​ULK3@Cytosol map → map GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi:​SUFU:​ULK3@Cytosol map
  13. SUFU@Cytosol map + GLI2-185*@Cytosol map → map ULK3@Cytosol map + GLI2-185*:​SUFU:​ULK3@Cytosol map
  14. SUFU@Cytosol map + GLI2-185*@Cytosol map + ULK3@Cytosol map → map GLI2-185*:​SUFU:​ULK3@Cytosol map
  15. GLI2-185*:​SUFU:​ULK3@Cytosol map → map GLI2-185*|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map
  16. GLI2-185*|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map → map GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map
  17. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map → map GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map
  18. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho@Cytosol map → map GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi@Proteosome map
  19. GLI2-185*|​pho|​active@Primary Cilium map → map GLI2-185*|​S805_unk|​pho|​active@Primary Cilium map
  20. GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus map → map GLI2-185*|​ubi|​ubi|​pho|​unk|​S956_emp|​active@Nucleus map
  21. GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus map + gpromoter_region@Nucleus map → map GLI2-185*|​pho:​promoter_region@Nucleus map
  22. GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus map → map GLI2-185*|​pho|​unk|​S956_pho|​active@Nucleus map
  23. GLI2-185*|​pho|​unk|​S956_pho|​active@Nucleus map + 14-3-3*@Nucleus map → map su_shh1_s_shh2_s110
  24. GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus map → map GLI2-185*|​pho|​unk|​S956_emp|​K757_ace|​active@Nucleus map
  25. GLI2-185*|​pho|​unk|​S956_emp|​K757_ace|​active@Nucleus map → map GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus map
As Catalyser:
  1. gFOXL1@Nucleus map → map rFOXL1@Nucleus map
  2. gFOXF1@Nucleus map → map rFOXF1@Nucleus map
  3. gFOXA2@Nucleus map → map rFOXA2@Nucleus map
  4. gFOXC2@Nucleus map → map rFOXC2@Nucleus map
  5. gFOXP3@Nucleus map → map rFOXP3@Nucleus map
  6. gFOXQ1@Nucleus map → map rFOXQ1@Nucleus map
  7. gRUNX2@Nucleus map → map rRUNX2@Nucleus map
  8. gJAG2@Nucleus map → map rJAG2@Nucleus map
  9. gFOXE1@Nucleus map → map rFOXE1@Nucleus map
  10. gFOXM1@Nucleus map → map rFOXM1@Nucleus map
  11. gCyclinD*@Nucleus map → map rCyclinD*@Nucleus map
  12. gTBX2@Nucleus map → map rTBX2@Nucleus map
  13. gPTCH1@Nucleus map → map rPTCH1@Nucleus map
  14. gSIX1@Nucleus map → map rSIX1@Nucleus map
  15. gGLI1@Nucleus map → map rGLI1@Nucleus map
  16. gBCL2@Nucleus map → map rBCL2@Nucleus map
  17. gHIP1*@Nucleus map → map rHIP1*@Nucleus map
  18. gMYCN@Nucleus map → map rMYCN@Nucleus map