Protein GLI1 map

Identifiers
GLI family zinc finger 1
HUGO:GLI1 hgnc_id:HGNC:4317 HGNC:4317 ENTREZ:2735 UNIPROT:P08151
HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

References
CASCADE:TGFB
CASCADE:HH
PMID:18754008
GLI1 and PTCH1 are expresed in fibroblast downstream of hedgehog (Hh) signalling.
PMID:17638910 ; PMID:22354771
GLI1, GLI2, GLI3 proteins are expressed in fibroblasts, GLI1 and GLI2 expression is upregulated by TGFB via SMAD3
Double-staining for ??-SMA and GLI1 or GLI2 demonstrated a prominent accumulation of both GLI transcription factors in myofibroblasts
PMID:19081070
The vertebrate GliRepressor function is largely derived from Gli3 while the primary GliActivator activity is largely contributed by Gli2. Gli1 is a transcriptional target of Hh signaling and acts as a transcriptional activator to reinforce GliA function
PMID:23031257
TGF-??1???Induced Fibroblast Differentiation Depends on SMO in Control Fibroblasts
Expression of collagen and actin (alphaSMA) and FN1 are SMO and GLI1/GLI2 dependent
PMID:11001584

GLI1|​ubi|​ubi@Cytosol

References
s_shh1_re90( Survival  map ):
References-begin:
PMID:20818436
PMID:17115028
PMID:17312394

GLI1@Nucleus

References
su_shh1_s_shh2_re7:( Survival  map ) PMID:12138125
su_shh1_s_shh2_re61:( Survival  map ) PMID:19996099

GLI1@Nucleus

References
s_shh2_re7:( Survival  map ) PMID:12138125
s_shh2_re61:( Survival  map ) PMID:19996099

GLI1|​pho|​pho@Nucleus

References
s_shh2_re7:( Survival  map ) PMID:12138125

GLI1|​T374_pho@Extracellular space

References
s_shh2_re14:( Survival  map ) PMID:16293631

GLI1|​S640_pho@Nucleus

References
s_shh2_re61:( Survival  map ) PMID:19996099

GLI1@Extracellular space

References
su_shh1_s_shh2_re10:( Survival  map ) PMID:12138125
su_shh1_s_shh2_re14:( Survival  map ) PMID:16293631
su_shh1_s_shh2_re119:( Survival  map ) PMID:17297467

Modifications:
In compartment: Cytosol
  1. GLI1@Cytosol map
  2. GLI1|​ubi|​ubi@Cytosol map
In compartment: Extracellular space
  1. GLI1@Extracellular space map
  2. GLI1|​T374_pho@Extracellular space map
In compartment: Nucleus
  1. GLI1@Nucleus map
  2. GLI1@Nucleus map
  3. GLI1|​K518_ace@Nucleus map
  4. GLI1|​S640_pho@Nucleus map
  5. GLI1|​pho|​pho@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. GLI1:​SUFU@Cytosol map
In compartment: Extracellular space
  1. CRM1*:​GLI1@Extracellular space map
In compartment: Nucleus
  1. CRM1*:​GLI1@Nucleus map
  2. GLI1|​pho|​pho:​promoter_region@Nucleus map
  3. GLI1|​pho|​pho:​JUN|​S63_pho|​S73_pho:​promoter_region@Nucleus map
  4. GLI1|​pho|​pho:​MSIN3*:​SAP18:​SUFU:​promoter_region@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. rGLI1@Cytosol map → map GLI1@Cytosol map
  2. GLI1@Cytosol map → map GLI1|​ubi|​ubi@Cytosol map
  3. GLI1@Cytosol map → map GLI1@Nucleus map
  4. SUFU@Cytosol map + GLI1@Cytosol map → map GLI1:​SUFU@Cytosol map
  5. GLI1:​SUFU@Cytosol map → map GLI1@Cytosol map + SUFU@Cytosol map
  6. CRM1*:​GLI1@Extracellular space map → map GLI1@Extracellular space map + CRM1*@Extracellular space map
  7. gpromoter_region@Nucleus map + GLI1|​pho|​pho@Nucleus map → map GLI1|​pho|​pho:​promoter_region@Nucleus map
  8. GLI1@Extracellular space map → map GLI1@Nucleus map
  9. GLI1@Extracellular space map → map GLI1|​T374_pho@Extracellular space map
  10. GLI1@Nucleus map → map GLI1|​S640_pho@Nucleus map
  11. 14-3-3*@Nucleus map + GLI1|​S640_pho@Nucleus map → map su_shh1_s_shh2_s104
  12. GLI1@Nucleus map → map GLI1|​K518_ace@Nucleus map
  13. GLI1|​K518_ace@Nucleus map → map GLI1@Nucleus map
  14. GLI1@Nucleus map → map GLI1|​pho|​pho@Nucleus map
  15. GLI1@Nucleus map + CRM1*@Nucleus map → map CRM1*:​GLI1@Nucleus map
  16. GLI1|​pho|​pho:​promoter_region@Nucleus map + SUFU@Nucleus map + SAP18@Nucleus map + MSIN3*@Nucleus map → map GLI1|​pho|​pho:​MSIN3*:​SAP18:​SUFU:​promoter_region@Nucleus map
  17. GLI1|​pho|​pho@Nucleus map + gpromoter_region@Nucleus map + JUN|​S63_pho|​S73_pho|​active@Nucleus map → map GLI1|​pho|​pho:​JUN|​S63_pho|​S73_pho:​promoter_region@Nucleus map
  18. CRM1*:​GLI1@Nucleus map → map CRM1*:​GLI1@Extracellular space map
As Catalyser:
  1. gCollagens*@Cytosol map → map rCollagens*@Cytosol map
  2. gPTCH*@Cytosol map → map rPTCH*@Cytosol map
  3. gACTA2@Cytosol map → map rACTA2@Cytosol map
  4. gFN*@Cytosol map → map rFN*@Cytosol map
  5. gMMP11@Nucleus map → map rMMP11@Nucleus map
  6. _beta_-Catenin*@Extracellular space map → map _beta_-Catenin*@Nucleus map
  7. gSFRP1@Nucleus map → map rSFRP1@Nucleus map
  8. gFOXA2@Nucleus map → map rFOXA2@Nucleus map
  9. gJAG2@Nucleus map → map rJAG2@Nucleus map
  10. gCyclinD*@Nucleus map → map rCyclinD*@Nucleus map
  11. gPTCH1@Nucleus map → map rPTCH1@Nucleus map
  12. gPAX6@Nucleus map → map rPAX6@Nucleus map
  13. gNKX2-2@Nucleus map → map rNKX2-2@Nucleus map
  14. gIGFBP6@Nucleus map → map rIGFBP6@Nucleus map
  15. gBCL2@Nucleus map → map rBCL2@Nucleus map
  16. gHIP1*@Nucleus map → map rHIP1*@Nucleus map
  17. gMYCN@Nucleus map → map rMYCN@Nucleus map
  18. gSNAI1@Nucleus map → map rSNAI1@Nucleus map
  19. gJUN@Nucleus map → map rJUN@Nucleus map
  20. gIL1R2@Nucleus map → map rIL1R2@Nucleus map
  21. gS100A9@Nucleus map → map rS100A9@Nucleus map
  22. gARC@Nucleus map → map rARC@Nucleus map
  23. gULK1@Nucleus map → map rULK1@Nucleus map