Identifiers
HGNC:3819
HUGO:FOXO1
forkhead box O1
HUGO:FOXO1, HGNC:3819, ENTREZ:2308, GENECARDS:GC13M041129, UNIPROT:Q12778????
HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778
HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1
FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / INHIBITING_CHECKPOINTS
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
Survival / WNT_NON_CANONICAL
References
PMID:19449109
PMID:25464856
PMID:15668399
References
an_re167:( Angiogenesis ) PMID:19449109
References
em_emtc_emtc_re250( EMT Senescence ):
PMID:11283613
Miz-1 regulates expression of p15INK4b
The Myc/Miz1 complex binds to the p15 promoter
Myc inhibits binding of p300 to Miz-1
Myc inhibits expression of p15INK4B by binding to Miz-1 (Myc represses p15INK4B by interacting with Miz1)
PMID:11283614
Disruption of the Myc-Miz1 interaction prevents repression of p15INK4B by Myc.
TGFB relieves Myc-mediated repression of p15INK4B by downregulating Myc bound to the p15INK4B transcriptional initiator region.
At the same time TGFB induces the formation of a Smad transcriptional complex that recognizes the p15INK4B promoter.
Is is proposed that by relieving the Myc-mediated repression of p15INK4B, TGFB allows this gene to be activated by the Smad complex.
TGFB signaling controls p15INK4B activation by 2 coupled events: transactivation and relief of repression.
PMID:10454538
Myc prevents inhibition of G1 CDKs by TGFB.
Inhibition of the p15 promoter by c-Myc.
Enforced expression of Myc abrogates p15INK4B induction and CDK inhibition by TGFB
Myc downregulation by TGFB is required for Activation of the p15Ink4b G1 Arrest Pathway
3 populations of endogenous CDK4: Latent pools (400 kDa, source of CDK4 for Cyclin D), Active CDK4-CyclinD complex, Inactive monomeric CDK4
References
s_akt2_re104:( Survival ) PMID:15668399
s_akt2_re159:( Survival ) PMID:17646672
s_akt2_re118:( Survival ) PMID:14664696
s_akt2_re121:( Survival ) PMID:11980723
References
s_akt2_re120:( Survival ) PMID:14664696
s_akt2_re125:( Survival ) PMID:11980723 PMID:14664696
s_akt2_re91:( Survival ) PMID:15668399
References
s_akt2_re91:( Survival ) PMID:15668399
References
s_akt2_re121:( Survival ) PMID:11980723
References
s_akt2_re122:( Survival ) PMID:11980723
s_akt2_re123:( Survival ) PMID:11980723 PMID:14664696
References
s_wnc2_re35:( Survival ) PMID:17662023
→ Survival@Cytosol
→ FOXO1|pho@Cytosol
→ FOXO1@Nucleus
→ FOXO*@Nucleus
+ FOXO1@Nucleus → FOXO1:PPARGC1A@Nucleus
→ FOXO*@Cytosol
→ FOXO*@Nucleus
→ gpromoter_region@Nucleus + FOXO1|T24_pho|S256_pho|S319_pho@Nucleus
+ 14-3-3*@Nucleus → su_akt1_s_akt2_s286
14-3-3*:FOXO1|T24_pho|S256_pho|S319_pho@Cytoplasm
→ 14-3-3*@Cytoplasm + FOXO1|T24_pho|S256_pho|S319_pho@Cytoplasm
→ FOXO1|T24_pho|S322_pho|S256_pho|S319_pho|S325_pho|S329_emp@Nucleus
→ FOXO1|T24_pho|S322_pho|S256_pho|S319_pho|S325_pho|S329_pho@Nucleus
+ CRM1*@Nucleus → CRM1*:FOXO1|T24_pho|S322_pho|S256_pho|S319_pho|S325_pho|S329_pho@Nucleus
→ CRM1*:FOXO1|T24_pho|S322_pho|S256_pho|S319_pho|S325_pho|S329_pho@Cytoplasm
→ FOXO1|T24_pho|S256_pho|S319_pho@Cytoplasm + CRM1*@Cytoplasm
+ RUNX2@Nucleus → su_akt1_s_akt2_s432
→ FOXO1|T24_pho|S256_pho|S319_pho@Nucleus
FOXO1|T24_pho|S256_pho|S319_pho:promoter_region@Nucleus
→ FOXO1|T24_pho|S322_ubi|S256_pho|S319_pho@Cytoplasm
→ FOXO1|pho|pho|pho@Cytoplasm
→ FOXO1|pho|emp|pho@Cytoplasm
+ FOXO1|pho|emp|pho@Cytoplasm → (FOXO1|pho|emp|pho:PPP3CB_sub_trunc_endsub_*:PPP3R*)|active@Cytoplasm
→ (FOXO1|pho|emp|pho:PPP3CB_sub_trunc_endsub_*:PPP3R*)|active@Nucleus