Identifiers
transforming growth factor beta receptor 2
HUGO:TGFBR2 hgnc_id:HGNC:11773 HGNC:11773 ENTREZ:7048 UNIPROT:P37173
transforming growth factor, beta receptor II (70/80kDa)
HUGO:TGFBR2, HGNC:11773, ENTREZ:7048, UNIPROT:P37173, GENECARDS:GC03P030623
HUGO:TGFBR2
MFS2 "transforming growth factor beta receptor II (70-80kD)"
HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / GROWTH_FACTORS_SIGNALING_PATHWAYS 
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / ECM 
 Innate Immunity   / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 

References
PMID:24132110,PMID:15265520
TGFB1, TGFB2, TGFB3 ligands bind to the type 2 TGF?? receptor (TGFBR2), which causes recruitment and phosphorylation of TGFBR1, resulting in downstream signalling activation.
PMID:24336330
TGFBR2 in CAFs
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
PMID:24132110
PMID:22703233
TGFBR2 upregulates expression of markers M2 activation as ARG1, MCR2 and LGALS3 (galecsin3) and induces AKT activation.
TGF-beta is known to cause a hetero-oligomerisation of the TGFBR1/TGFBR2 complex consisting of two TGFBR1 and two TGFBR2 molecules to activate it (not modelled).
Besides cellular stresses the SAPK pathways are also activated by cytokines such as TGF-beta. Smad-dependent gene expression can provoke P38 activation in response to TGFbeta.
PMID:20060931 PMID:21614932

References
em_emtc_emtc_re119:( EMT Senescence  ) PMID:16474430

1. TGFBR2@Cytosol
2. TGFBR2|​hm2@Cytosol
3. TGFBR2|​ubi@Cytosol

1. TGFBR2@INNATE_IMMUNE_CELL_Membrane

1. TAB*:​TAK1*|​pho:​TGFBR1:​TGFBR2@Cytoplasm

1. IQGAP1 :​TGFBR2@Cytosol
2. TGFB1|​hm2:​TGFBR2|​hm2@Cytosol
3. TGFB*:​TGFBR1:​TGFBR2@Cytosol
4. TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol
5. TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol
6. Occludin*:​PARD6A:​TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol
7. Occludin*:​PARD6A|​S345_pho:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol

1. SARA*:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Early Endosome

1. TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane

1. TGFBR1:​TGFBR2@Plasma Membrane
2. TAB*:​TGFBR1:​TGFBR2@Plasma Membrane

1. TGFBR1@Cytosol + TGFBR2@Cytosol + TGFB*@default → TGFB*:​TGFBR1:​TGFBR2@Cytosol
2. rTGFBR2@Cytosol → TGFBR2@Cytosol
3. TGFBR2|​ubi@Cytosol → degraded
4. TGFBR2@Cytosol → TGFBR2|​ubi@Cytosol
5. IQGAP1 :​TGFBR2@Cytosol → degraded
6. IQGAP1 @Cytosol + TGFBR2@Cytosol → IQGAP1 :​TGFBR2@Cytosol
7. TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol → TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol
8. TGFBR2@Cytosol → TGFBR2|​hm2@Cytosol
9. TGFB1|​hm2|​active@Extracellular space + TGFBR2|​hm2@Cytosol → TGFB1|​hm2:​TGFBR2|​hm2@Cytosol
10. TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol + ATP@Extracellular space → TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol + ADP@Extracellular space
11. TGFB1|​hm2:​TGFBR2|​hm2@Cytosol + TGFBR1|​hm2@Cytosol → TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol
12. SARA*@Early Endosome + TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol → SARA*:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Early Endosome
13. Occludin*:​PARD6A:​TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol + ATP@Cytosol → Occludin*:​PARD6A|​S345_pho:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol + ADP@Cytosol
14. Occludin*:​PARD6A:​TGFBR1|​hm2@Cytosol + TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol → Occludin*:​PARD6A:​TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol
15. TGFBR1@INNATE_IMMUNE_CELL_Membrane + TGFBR2@INNATE_IMMUNE_CELL_Membrane + TGFB*@default → TGFB*:​TGFBR1:​TGFBR2@INNATE_IMMUNE_CELL_Membrane
16. rTGFBR2@INNATE_IMMUNE_CELL_Cytosol → TGFBR2@INNATE_IMMUNE_CELL_Membrane
17. TGFBR1:​TGFBR2@Plasma Membrane + TAB*@Cytoplasm → TAB*:​TGFBR1:​TGFBR2@Plasma Membrane
18. TAK1*@Cytoplasm + TAB*:​TGFBR1:​TGFBR2@Plasma Membrane → TAB*:​TAK1*|​pho:​TGFBR1:​TGFBR2@Cytoplasm

1. gTGFB*@Cytosol → rTGFB*@Cytosol
2. SMAD3@Cytosol → SMAD3|​pho@Cytosol
3. SMAD2@Cytosol → SMAD2|​pho@Cytosol
4. gEGF@Cytosol → rEGF@Cytosol
5. TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol + ATP@Extracellular space → TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol + ADP@Extracellular space
6. SHC1_p66_p52*@Cytosol → SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol
7. TRAF6@Cytosol → TRAF6|​ubi|​hm2|​active@Cytosol
8. SARA*:​SMAD2@Early Endosome + ATP@Cytosol → SARA*:​SMAD2|​S467_pho|​S465_pho@Early Endosome + ADP@Cytosol
9. SARA*:​SMAD3@Early Endosome + ATP@Cytosol → SARA*:​SMAD3|​S423_pho|​S425_pho@Early Endosome + ADP@Cytosol
10. Occludin*:​PARD6A:​TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol + ATP@Cytosol → Occludin*:​PARD6A|​S345_pho:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol + ADP@Cytosol
11. gLGALS3@INNATE_IMMUNE_CELL_Cytosol → rLGALS3@INNATE_IMMUNE_CELL_Cytosol
12. gMRC2@MARKERS_MACROPHAGE → rMRC2@MARKERS_MACROPHAGE
13. gCCL5@INNATE_IMMUNE_CELL_Cytosol → rCCL5@INNATE_IMMUNE_CELL_Cytosol
14. AKT*@INNATE_IMMUNE_CELL_Cytosol → AKT*|​pho@INNATE_IMMUNE_CELL_Cytosol
15. SMAD3@INNATE_IMMUNE_CELL_Cytosol → SMAD3|​pho@INNATE_IMMUNE_CELL_Cytosol
16. SMAD2@INNATE_IMMUNE_CELL_Cytosol → SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol
17. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol → O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol
18. gCCL3@INNATE_IMMUNE_CELL_Cytosol → rCCL3@INNATE_IMMUNE_CELL_Cytosol
19. gCCL2@INNATE_IMMUNE_CELL_Cytosol → rCCL2@INNATE_IMMUNE_CELL_Cytosol
20. MAP2K4@Cytoplasm → MAP2K4|​pho|​pho@Cytoplasm
21. MAP2K6@Cytoplasm → MAP2K6|​pho|​pho@Cytoplasm
22. SMAD2@Cytoplasm + SMAD4@Cytoplasm → su_mpk1_mpk1_s1028
23. SMAD3@Cytoplasm + SMAD4@Cytoplasm → su_mpk1_mpk1_s1027