Complex TGFBR1:TGFBR2 map
Complex composition:

  1. TGFBR1 map
  2. TGFBR2 map

TGFBR1:​TGFBR2@Plasma Membrane

Identifiers
NAME:TGFBR1:TGFBR2

References
su_mpk1_mpk1_re129( Survival  map ):
Activated TGFBR1/TGFBR2 complex attracts the TAB2/TAB3 proteins which promote activation of TAK1 (by phosphorylation).
TAB1 is an essential cofactor required for activation of TAK1 by upstream stimuli.
PMID:20060931 PMID:11274345
su_mpk1_mpk1_re251( Survival  map ):
TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes.
PMID:21614932

Modifications:
Participates in complexes:
In compartment: Plasma Membrane
  1. TGFBR1:​TGFBR2@Plasma Membrane map
Participates in reactions:
As Reactant or Product:
  1. TGFBR1:​TGFBR2@Plasma Membrane map + TAB*@Cytoplasm map → map TAB*:​TGFBR1:​TGFBR2@Plasma Membrane map
As Catalyser:
  1. SMAD2@Cytoplasm map + SMAD4@Cytoplasm map → map su_mpk1_mpk1_s1028
  2. SMAD3@Cytoplasm map + SMAD4@Cytoplasm map → map su_mpk1_mpk1_s1027