Identifiers
mitogen-activated protein kinase kinase kinase 7
HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318
TAK1
HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7
MEKK7
MEKK7 TAK1

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 
 Survival   / WNT_CANONICAL 
 Survival   / WNT_NON_CANONICAL 

References
synonym:TAK1
PMID:23070005
TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways.
Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6.
PMID:18855897 PMID:11274345

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

References
rc_re1339:( Regulated Cell Death  ) from uniprot
rc_re334( Regulated Cell Death  ):
PMID:15509864
review
PMID:16054095
by CAMKK2
PMID:16054096
PMID:17244528
by calcium via CAMKK2 and AMPK
PMID:15980064
by CAMKK
PMID:18692468
propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity.
PMID:19197243
in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure
in MCF10A upon Ca2+ by CAMKK2
High Calcium lvl activate CAMKK2 enzyme and leads to AMPK activation
PMID:19037093PMID:17244528
PMID:20484410
rc_re1342( Regulated Cell Death  ):
PMID:20531300
PMID:11340079
FLASH coordinates NF-kappa B activity via TRAF2

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

References
rc_re1340:( Regulated Cell Death  ) from uniprot

References
su_mpk1_mpk1_re130( Survival  ):
Activated TGFBR1/TGFBR2 complex attracts the TAB2/TAB3 proteins which promote activation of TAK1 (by phosphorylation).
TAB1 is an essential cofactor required for activation of TAK1 by upstream stimuli. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF.
PMID:20060931 PMID:11274345
su_mpk1_mpk1_re131( Survival  ):
Endogenous TAK1 is activated by TGF-beta IL-1 and TNF.
PMID:11274345
su_wca1_s_wca3_re30:( Survival  ) PMID:20538596
su_wca1_s_wca3_re143:( Survival  ) PMID:15082531

1. TAK1*@Cytoplasm
2. TAK1*@Cytoplasm

1. TAK1*@Cytosol

1. TAK1*@TNFRSF1 Receptor Complex
2. TAK1*|​T187_pho@TNFRSF1 Receptor Complex

1. TAB1:​TAK1*@Cytoplasm
2. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm
3. TAB1:​TAB2:​TAK1*|​emp@Cytoplasm
4. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm
5. TAK1*|​pho:​TNFRSF1B:​TRAF2@Cytoplasm
6. TAB*:​TAK1*|​pho:​TGFBR1:​TGFBR2@Cytoplasm
7. RCAN*|​S94_pho|​S136_pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm
8. IL1R1:​IRAK1:​MYD88:​TAK1*|​pho:​TRAF6@Cytoplasm
9. RIPK1:​TAK1*|​pho:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm
10. FZD*:​ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho:​WNT3@Cytoplasm

1. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus
2. NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus

1. TAB*:​TAK1*:​XIAP@TNFRSF1 Receptor Complex

1. TAK1*@Cytosol → TAK1*@TNFRSF1 Receptor Complex
2. TAK1*@TNFRSF1 Receptor Complex → TAK1*|​T187_pho@TNFRSF1 Receptor Complex
3. TAK1*|​T187_pho@TNFRSF1 Receptor Complex → TAK1*@TNFRSF1 Receptor Complex
4. XIAP@TNFRSF1 Receptor Complex + TAK1*@TNFRSF1 Receptor Complex + TAB*@TNFRSF1 Receptor Complex → TAB*:​TAK1*:​XIAP@TNFRSF1 Receptor Complex
5. TAK1*@Cytoplasm + TAB*:​TGFBR1:​TGFBR2@Plasma Membrane → TAB*:​TAK1*|​pho:​TGFBR1:​TGFBR2@Cytoplasm
6. TAK1*@Cytoplasm + IL1R1:​IRAK1:​MYD88:​TRAF6@Plasma Membrane → IL1R1:​IRAK1:​MYD88:​TAK1*|​pho:​TRAF6@Cytoplasm
7. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane + TAK1*@Cytoplasm → RIPK1:​TAK1*|​pho:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm
8. TNFRSF1B:​TRAF2@Plasma Membrane + TAK1*@Cytoplasm → TAK1*|​pho:​TNFRSF1B:​TRAF2@Cytoplasm
9. TAK1*@Cytoplasm → TGF-_beta_ pathway@Nucleus
10. FZD*:​ROR2:​WNT1_3*@Cytoplasm → TAB1:​TAK1*@Cytoplasm
11. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus + NLK|​T286_pho|​hm2|​active@Nucleus + TAB2@Nucleus → NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus
12. TAK1*@Cytoplasm + TAB1@Cytoplasm → TAB1:​TAK1*@Cytoplasm
13. TAB1:​TAK1*@Cytoplasm → TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm
14. TAK1*@Cytoplasm → Immune system@Extracellular space
15. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm → TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus
16. TGF-_beta_ pathway@Extracellular space → TAB1:​TAB2:​TAK1*|​pho@Cytoplasm
17. RCAN*|​T192_pho@Cytoplasm + TAB1:​TAB2:​TAK1*|​pho@Cytoplasm → RCAN*|​S94_pho|​S136_pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm
18. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm → TAB1:​TAB2:​TAK1*|​emp@Cytoplasm
19. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm + FZD*:​ROR2|​pho:​WNT3@Cytoplasm → FZD*:​ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho:​WNT3@Cytoplasm
20. FZD*:​ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho:​WNT3@Cytoplasm → WNT canonical pathway@Cytoplasm

1. CHUK:​IKBKG:​IKK_beta_*@TNFRSF1 Receptor Complex → CHUK:​IKBKG:​IKK_beta_*|​pho@TNFRSF1 Receptor Complex
2. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol → AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytosol
3. MAP2K4@Cytoplasm → MAP2K4|​pho|​pho@Cytoplasm
4. MAP2K6@Cytoplasm → MAP2K6|​pho|​pho@Cytoplasm
5. LEF_TCF*@Nucleus → LEF_TCF*|​S166_pho|​T155_pho@Nucleus
6. TAB1:​TAK1*@Cytoplasm → TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm
7. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm → Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus
8. FZD*:​ROR2:​WNT3@Cytoplasm → FZD*:​ROR2|​pho:​WNT3@Cytoplasm