Simple molecule O_sub_2_endsub__super_-_endsuper_ map
O_sub_2_endsub__super_-_endsuper_@Cytosol

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map

References
PMID:15927447; PMID:19995913
Nox4, in contrast to other Nox proteins, produces large amounts of hydrogen peroxide constitutively. Known cytosolic oxidase proteins or the GTPase Rac are not required for this activity. Nox4 associates with the protein p22phox on internal membranes, where ROS generation occurs. Knockdown and gene transfection studies confirmed that Nox4 requires p22phox for ROS generation
ca_re649( Cancer Associated Fibroblasts  map ):
PMID:19732719
Inhibition of TGF-?? signaling??in vivo??increases CD11b+??cell cytotoxicity via an oxygen radical-dependent mechanism (superoxide?? and H2O2 production) in neutrophils

O_sub_2_endsub__super_-_endsuper_@Mitochondrial Matrix

Identifiers
CHEBI:18421 KEGGCOMPOUND:C00704 CAS:11062-77-4

References
rc_re73:( Regulated Cell Death  map ) PMID:15807660
rc_re81:( Regulated Cell Death  map ) reactionType:is.a

O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

Identifiers
CHEBI:18421, KEGGCOMPOUND:C00704, CAS:11062-77-4

References
PMID:19372727
The enzyme responsible for O2???- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.

O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / NO_ROS_PRODUCTION  map

References
PMID:19372727
The enzyme responsible for O2???- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.
PMID:19732719
Inhibition of TGF-?? signaling??in vivo??increases CD11b+??cell cytotoxicity via an oxygen radical-dependent mechanism (superoxide?? and H2O2 production) in neutrophils

Modifications:
In compartment: Cytosol
  1. O_sub_2_endsub__super_-_endsuper_@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Mitochondrial Matrix
  1. O_sub_2_endsub__super_-_endsuper_@Mitochondrial Matrix map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. O_sub_2_endsub_@Cytosol map → map O_sub_2_endsub__super_-_endsuper_@Cytosol map
    2. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map H_sub_2_endsub_O_sub_2_endsub_@Cytosol map
    3. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map ROS production@Cytosol map
    4. O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map H_sub_2_endsub_O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    5. O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    6. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map
    7. O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map → map ROS_production@default map
    8. O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map → map H_sub_2_endsub_O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map
    9. O_sub_2_endsub_@Cytosol map + NADPH@Cytosol map → map O_sub_2_endsub__super_-_endsuper_@Cytosol map + NADP_super_+_endsuper_@Cytosol map
    10. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map H_sub_2_endsub_O_sub_2_endsub_@Cytosol map
    11. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map ROS@Cytosol map
    12. NADH@Mitochondrial Matrix map + O_sub_2_endsub_@Mitochondrial Matrix map → map NAD_super_+_endsuper_@Mitochondrial Matrix map + O_sub_2_endsub__super_-_endsuper_@Mitochondrial Matrix map
    13. O_sub_2_endsub__super_-_endsuper_@Mitochondrial Matrix map → map O_sub_2_endsub_@Mitochondrial Matrix map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial Matrix map
    14. O_sub_2_endsub__super_-_endsuper_@Mitochondrial Matrix map → map ROS@Mitochondrial Matrix map
    15. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map ROS@Cytosol map
    16. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map O_sub_2_endsub_@Cytosol map + H_sub_2_endsub_O_sub_2_endsub_@Cytosol map
    17. ubiquinol@Mitochondrial inner membrane map + O_sub_2_endsub_@Mitochondrial Matrix map → map ubiquinone@Mitochondrial inner membrane map + O_sub_2_endsub__super_-_endsuper_@Mitochondrial Matrix map
    As Catalyser: