Reaction known_transition_omitted em_emtc_emtc_re1272 map

SHC1_p66_p52*@Cytosol map → SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map

Reaction regulators:
Catalysis
  1. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map
  2. FGFR1|​hm2|​active@Cytosol map
  3. FGFR3|​hm2|​active@Cytosol map
  4. FGFR4|​hm2|​active@Cytosol map
  5. c-SRC*|​Y_pho|​active@Cytosol map
  6. IGF family*:​IGF1R|​Y_pho|​hm2@Cytosol map
  7. TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol map


References
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
PMID:12767520
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates SHC1, leading to cellular proliferation