Identifiers
HUGO:TGFB1 HUGO:TGFB2 HUGO:TGFB3
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / GROWTH_FACTORS_PRODUCTION
References
CASCADE:TNF
CASCADE:TGFB
PMID:15653932
Treatment of fibroblasts with TNF-?? resulted in a significant increase in TGF-??1 protein as measured by ELISA. The increase in protein was preceded by a 200???400% increase in TGF-??1 mRNA detected by quantitative, real-time, reverse transcriptase???polymerase chain reaction. Western blot analysis showed that TNF-?? activated the extracellular signal???regulated kinase (ERK), and inhibitors of the ERK-specific mitogen-activated protein kinase pathway (PD98059 or U0126) blocked TNF-?? induction of TGF-??1
PMID:21098712
Exosomal TGF-??, resulted in an enhanced induction of TGF-??-mRNA in fibroblasts via TGFBR1