Complex TGFB1:TGFBR2 map
Complex composition:

  1. TGFBR2 map
  2. TGFB1 map

TGFB1|​hm2:​TGFBR2|​hm2@Cytosol

Identifiers
NAME:TGFB1:TGFBR2

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
Reference_bigin:
PMID:22943793
TGFb binds to homodimer TGFBR2 first
TGFBR2 phosphorylates the GS domain of homodimeric TFGBR1 on serine residues
This phosphorylation leads to incorporation of TGFBR1 and formation of a large ligand-receptor complex of fimeric TGFB and two pairs of TGFBR1 and TGFBR2
PMID:12809600
PMID:22710166
The active ligand???receptor complex is a heterotetrameric complex
This complex consists of an active dimer of TGFB and homodimers of both TGFBRI and TGFBR2.
Within the active receptor complex, TGFBR2autophosphorylates itself and catalyzes transphosphorylation of the TGFBR1.
Transphosphorylation of the TGFBRI activates its kinase activity.
Reference_end

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. TGFB1|​hm2:​TGFBR2|​hm2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. TGFB1|​hm2|​active@Extracellular space map + TGFBR2|​hm2@Cytosol map → map TGFB1|​hm2:​TGFBR2|​hm2@Cytosol map
  2. TGFB1|​hm2:​TGFBR2|​hm2@Cytosol map + TGFBR1|​hm2@Cytosol map → map TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol map
As Catalyser: