Complex TAB*:TGFBR1:TGFBR2 map
Complex composition:

  1. TGFBR2 map
  2. TAB* map
  3. TGFBR1 map

TAB*:​TGFBR1:​TGFBR2@Plasma Membrane

Identifiers
NAME:TAB*:TGFBR1:TGFBR2

References
su_mpk1_mpk1_re129( Survival  map ):
Activated TGFBR1/TGFBR2 complex attracts the TAB2/TAB3 proteins which promote activation of TAK1 (by phosphorylation).
TAB1 is an essential cofactor required for activation of TAK1 by upstream stimuli.
PMID:20060931 PMID:11274345
su_mpk1_mpk1_re130( Survival  map ):
TAB1 is an essential cofactor required for activation of TAK1 by upstream stimuli. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF.

Modifications:
Participates in complexes:
In compartment: Plasma Membrane
  1. TAB*:​TGFBR1:​TGFBR2@Plasma Membrane map
Participates in reactions:
As Reactant or Product:
  1. TGFBR1:​TGFBR2@Plasma Membrane map + TAB*@Cytoplasm map → map TAB*:​TGFBR1:​TGFBR2@Plasma Membrane map
  2. TAK1*@Cytoplasm map + TAB*:​TGFBR1:​TGFBR2@Plasma Membrane map → map TAB*:​TAK1*|​pho:​TGFBR1:​TGFBR2@Cytoplasm map
As Catalyser: