Protein TAB* map

Identifiers
HUGO:TAB1 HUGO:TAB2 HUGO:TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 2
HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8
TGF-beta activated kinase 1/MAP3K7 binding protein 3
HUGO:TAB3 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8
TGF-beta activated kinase 1/MAP3K7 binding protein 1
MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1"
HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750
MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2"
MAP3K7IP3 "mitogen-activated protein kinase kinase kinase 7 interacting protein 3"

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:16200688 PMID:15282297 PMID:24403530
TAK1 is the only MAP3K that requires the adapter proteins TAB123 for its activation.
PMID:20060931

TAB*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map

References
rc_re1212:( Regulated Cell Death  map ) reactionType:is.a
rc_re1214( Regulated Cell Death  map ):
PMID:23010170
K63-linked polyubiquitination of RIP1 provides a scaffold for the recruitment of TGF-beta-activated kinase 1 (TAK1) binding protein 2 and 3 (TAB2 and 3),
which finally activates TAK1

TAB*@TNFRSF1 Receptor Complex

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map

References
rc_re1214( Regulated Cell Death  map ):
PMID:23010170
K63-linked polyubiquitination of RIP1 provides a scaffold for the recruitment of TGF-beta-activated kinase 1 (TAK1) binding protein 2 and 3 (TAB2 and 3),
which finally activates TAK1

TAB*@Cytoplasm

References
su_mpk1_mpk1_re129( Survival  map ):
Activated TGFBR1/TGFBR2 complex attracts the TAB2/TAB3 proteins which promote activation of TAK1 (by phosphorylation).
TAB1 is an essential cofactor required for activation of TAK1 by upstream stimuli.
PMID:20060931 PMID:11274345

Modifications:
In compartment: Cytoplasm
  1. TAB*@Cytoplasm map
In compartment: Cytosol
  1. TAB*@Cytosol map
In compartment: TNFRSF1 Receptor Complex
  1. TAB*@TNFRSF1 Receptor Complex map
In compartment: T_cell
  1. TAB*@T_cell map
Participates in complexes:
In compartment: Cytoplasm
  1. TAB*:​TAK1*|​pho:​TGFBR1:​TGFBR2@Cytoplasm map
In compartment: Plasma Membrane
  1. TAB*:​TGFBR1:​TGFBR2@Plasma Membrane map
In compartment: TNFRSF1 Receptor Complex
  1. TAB*:​TAK1*:​XIAP@TNFRSF1 Receptor Complex map
In compartment: T_cell
  1. MAP3K7:​TAB*|​pho@T_cell map
Participates in reactions:
As Reactant or Product:
  1. TAB*@T_cell map + MAP3K7@T_cell map → map MAP3K7:​TAB*|​pho@T_cell map
  2. MAP3K7:​TAB*|​pho@T_cell map → map TAB*@T_cell map + MAP3K7@T_cell map
  3. TAB2@Cytosol map → map TAB*@Cytosol map
  4. TAB3@Cytosol map → map TAB*@Cytosol map
  5. TAB*@Cytosol map → map TAB*@TNFRSF1 Receptor Complex map
  6. XIAP@TNFRSF1 Receptor Complex map + TAK1*@TNFRSF1 Receptor Complex map + TAB*@TNFRSF1 Receptor Complex map → map TAB*:​TAK1*:​XIAP@TNFRSF1 Receptor Complex map
  7. TGFBR1:​TGFBR2@Plasma Membrane map + TAB*@Cytoplasm map → map TAB*:​TGFBR1:​TGFBR2@Plasma Membrane map
  8. TAK1*@Cytoplasm map + TAB*:​TGFBR1:​TGFBR2@Plasma Membrane map → map TAB*:​TAK1*|​pho:​TGFBR1:​TGFBR2@Cytoplasm map
As Catalyser:
  1. MAP2K4@T_cell map → map MAP2K4|​pho@T_cell map
  2. IKBKG:​IKK_alpha_*:​IKK_beta_*@T_cell map → map IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@T_cell map
  3. gIL2RA@T_cell map → map rIL2RA@T_cell map
  4. gFOXP3@T_cell map → map rFOXP3@T_cell map
  5. MAP2K3@T_cell map → map MAP2K3|​pho@T_cell map
  6. MAP2K6@T_cell map → map MAP2K6|​pho@T_cell map
  7. TAK1*@Cytosol map → map TAK1*@TNFRSF1 Receptor Complex map
  8. MAP2K4@Cytoplasm map → map MAP2K4|​pho|​pho@Cytoplasm map
  9. MAP2K6@Cytoplasm map → map MAP2K6|​pho|​pho@Cytoplasm map