Protein IQGAP1 map

Identifiers
HUGO:IQGAP1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map

References
PMID:23454766
IQ motif containing GTPase activating protein 1 (IQGAP1) binds to TGF-?? receptor II (T??RII) and suppresses T??RII-mediated signaling in pericytes to prevent myofibroblastic differentiation in the tumor microenvironment.
TGF-??1 stimulation increases IQGAP1/T??RII binding.

Modifications:
In compartment: Cytosol
  1. IQGAP1 @Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. IQGAP1 :​TGFBR2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IQGAP1 @Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
  2. IQGAP1 :​TGFBR2@Cytosol map → map degraded
  3. IQGAP1 @Cytosol map + TGFBR2@Cytosol map → map IQGAP1 :​TGFBR2@Cytosol map
As Catalyser: