RNA CCL5 map

Identifiers
HUGO:CCL5

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
PMID:23171795
Downregulation of miR-31 and miR-214 and upregulation of miR-155 was confirmed in all CAF and induced CAF samples;
CCL5 is a Target of miR-214 . The CCL5 secreted by CAFs is a key tumor-promoting factor.
 NEUTROPHIL  map
CASCADE:TGFB
PMID:19732719??
Inhibition of TGF-?? signaling downregulates Arginase1, CCL5 and CCL2 expression and upregulates TNF, ICAM1,CCL3 expression (mRNA) in tumor neutrophiles (TAN)

Modifications:
In compartment: Cytosol
  1. rCCL5@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rCCL5@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CCL5:​MIR214@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. gCCL5@Cytosol map → map rCCL5@Cytosol map
  2. rCCL5@Cytosol map → map CCL5@Cytosol map
  3. CCL5:​MIR214@Cytosol map → map degraded
  4. arMIR214@Cytosol map + rCCL5@Cytosol map → map CCL5:​MIR214@Cytosol map
  5. gCCL5@INNATE_IMMUNE_CELL_Cytosol map → map rCCL5@INNATE_IMMUNE_CELL_Cytosol map
  6. rCCL5@INNATE_IMMUNE_CELL_Cytosol map → map CCL5@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: