Reaction heterodimer_association su_mpk1_mpk1_re251 map

SMAD2@Cytoplasm map + SMAD4@Cytoplasm map → su_mpk1_mpk1_s1028

Reaction regulators:
Catalysis
  1. TGFBR1:​TGFBR2@Plasma Membrane map


References
TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes.
PMID:21614932