Identifiers
HUGO:PRKACA HUGO:PRKACB HUGO:PRKACG
HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612
Protein kinase cAMP-depenedent catalytic alpha
HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA
Protein kinase cAMP-depenedent catalytic beta
HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB
Protein kinase cAMP-depenedent catalytic gamma
HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / INHIBITING_CHECKPOINTS 
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity   / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / HEDGEHOG 

References
PMID:11181701 PMID:17371980
REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA
REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB
PMID:18501881, PMID:7890616
Intracellular Ca2+??release induces cAMP Accumulation in Human Monocytes and activation of PKA signaling downstream of IL13.
IL-13 significantly inhibits the ROS generation in all macrophage types, probably, via PLC/Ca2+/cAMP/PKA pathway
PMID:10925299
IL13 activates Arginase activity downstream of cAMP/PKA
PMID:20027184

References
in_re475( Innate Immunity  ):
PMID:10925299
IL13 activates Arginase activity downstream of cAMP/PKA
PMID:14568929, PMID:10925299
IL13 induces arginase activity which results in L-arginin deficiency. L-arginin deficiency impairs iNOS protein synthesis and stability.
p38 MAPK participates in arginase activation??downstream of IL13

References
s_shh1_re51:( Survival  ) PMID:20016067
su_shh1_s_shh2_re61:( Survival  ) PMID:19996099

References
s_shh1_re52:( Survival  ) PMID:20016067

References
su_shh1_s_shh1_re43:( Survival  ) PMID:21209912

References
s_shh2_re61:( Survival  ) PMID:19996099

References
su_shh1_s_shh2_re14:( Survival  ) PMID:16293631

1. PKA*@Cytosol

1. PKA*@Extracellular space

1. PKA*@INNATE_IMMUNE_CELL_Cytosol

1. PKA*@Nucleus
2. PKA*@Nucleus

1. PKA*@Primary Cilium

1. PKA*|​hm2|​active@T_cell

1. PKA*:​PKA_R*@INNATE_IMMUNE_CELL_Cytosol
2. PKA*:​PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol

1. AKAP*:​PKA*@Primary Cilium

1. PKA*|​hm2:​PKA1_R|​hm2@T_cell

1. PKA*|​hm2:​PKA1_R|​hm2@T_cell → PKA1_R|​hm2@T_cell + PKA*|​hm2|​active@T_cell
2. cAMP@INNATE_IMMUNE_CELL_Cytosol + PKA*:​PKA_R*@INNATE_IMMUNE_CELL_Cytosol → PKA*:​PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol
3. PKA*:​PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol → PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol + PKA*@INNATE_IMMUNE_CELL_Cytosol
4. PKA*@INNATE_IMMUNE_CELL_Cytosol → ROS_production@default
5. PKA*@Cytosol → PKA*@Cytosol
6. AKAP*:​PKA*@Primary Cilium → PKA*@Primary Cilium + AKAP*@Primary Cilium
7. PKA*@Primary Cilium → PKA*@Cytosol
8. PKA*@Primary Cilium → PKA*@Nucleus
9. AKAP*@Primary Cilium + PKA*@Primary Cilium → AKAP*:​PKA*@Primary Cilium

1. CSK@T_cell → CSK|​S364_pho|​active@T_cell
2. L-arginine@INNATE_IMMUNE_CELL_Cytosol → Urea@INNATE_IMMUNE_CELL_Cytosol + L-ornitine@INNATE_IMMUNE_CELL_Cytosol
3. GLI2-185*:​KIF7:​SUFU:​ULK3@Cytosol → GLI2-185*:​KIF7:​SUFU:​ULK3@Primary Cilium
4. GLI3-190*|​S849_emp:​KIF7:​SUFU:​ULK3@Cytosol → GLI3-190*|​S849_emp:​KIF7:​SUFU:​ULK3@Primary Cilium
5. GLI3-190*|​S849_emp:​SUFU:​ULK3@Cytosol → GLI3-190*|​S849_pho|​S907_pho|​S865_pho|​S877_pho|​S1006_pho|​S980_pho:​SUFU:​ULK3@Cytosol
6. GLI2-185*:​SUFU:​ULK3@Cytosol → GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho:​SUFU:​ULK3@Cytosol
7. GLI1@Extracellular space → GLI1|​T374_pho@Extracellular space
8. GLI1@Nucleus → GLI1|​S640_pho@Nucleus
9. GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus → GLI2-185*|​pho|​unk|​S956_pho|​active@Nucleus
10. GLI3-190*|​unk|​active@Nucleus → GLI3-190*|​unk|​pho|​active@Nucleus