Reaction state_transition rc_re336 map

AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map → AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytosol map

Reaction regulators:
Catalysis
  1. CAB39:​STK11|​K48_unk|​T366_unk|​active:​STRADA@Cytosol map
  2. High AMP/ATP ratio@Cytosol map
Inhibition
  1. glucose@Cytosol map
  2. PKA_C*@Cytosol map
  3. Low AMP/ATP ratio@Cytosol map


References
PMID:15509864
review
PMID:8910387
by LKB1, from rat enzyme
LKB1 dependent AMPK phosphorylation induced by glucose starvation
PMID:19197243
in MCF10A upon starvation by LKB1
PMID:20160076
in EBV-immortalized B-lymphocytes from healthy individuals, but not from ATM-deficient AT patients, upon H2O2PMID:12546687
In normoxic cells, the very low AMP/ATP ratio (about 0.05) keeps AMPK mainly in the inactive form
PMID:19942859
PMID:23030059