Protein Caspase8,10* map

Identifiers
symbol withdrawn, see
HUGO:A2MRAP~withdrawn HGNC:10

References
PMID:20531300
PMID:16498403
PMID:11583996
PMID:23377657
apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation
PMID:27984721

Modifications:
In compartment: Cytosol
  1. Caspase8,10*@Cytosol map
  2. Caspase8,10*|​ubi|​active@Cytosol map
Participates in complexes:
In compartment: Autopagosome
  1. ATG5:​Caspase8,10*|​ubi:​FADD@Autopagosome map
  2. Caspase8,10*|​ubi:​LC3-I*:​SQSTM1@Autopagosome map
In compartment: Cytosol
  1. Caspase8,10*:​FLASH*@Cytosol map
  2. Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
  3. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map
  4. CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map
In compartment: Endosome
  1. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  2. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  3. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map
Participates in reactions:
As Reactant or Product:
  1. Caspase8*@Cytosol map → map Caspase8,10*@Cytosol map
  2. Caspase10*@Cytosol map → map Caspase8,10*@Cytosol map
  3. rc_s5142 + Caspase8,10*@Cytosol map → map Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
  4. CUL3:​RBX1@Cytosol map + Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map → map CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map
  5. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map → map Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
  6. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map → map rc_s6308
  7. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map + CFLAR@Cytosol map + RIPK1@Cytosol map + RIPK3@Cytosol map + MLKL@Cytosol map → map CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map + CUL3:​RBX1@Cytosol map
  8. Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map + TRAF2@Cytosol map + IKBKG@Cytosol map + TRADD@Cytosol map + RIPK1@Cytosol map → map Caspase10*:​Caspase8*@Cytosol map
  9. CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map → map RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map
  10. FLASH*@Cytosol map + Caspase8,10*@Cytosol map → map Caspase8,10*:​FLASH*@Cytosol map
  11. FASLG:​FAS|​pal@Cytosol map + Caspase8,10*:​FLASH*@Cytosol map + FAF1@Cytosol map + FADD@Cytosol map + DAXX@Cytosol map + RIPK1@Cytosol map → map Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  12. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  13. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map
  14. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map
  15. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map ASK1*@Cytosol map
  16. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  17. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  18. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map Caspase8*|​ubi:​FLASH*@Cytosol map
  19. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map → map rc_s6308
  20. rc_s6308 → map Caspase8,10*|​ubi|​active@Cytosol map
  21. LC3-I*:​SQSTM1@Autopagosome map + Caspase8,10*|​ubi|​active@Cytosol map → map Caspase8,10*|​ubi:​LC3-I*:​SQSTM1@Autopagosome map
  22. ATG5@Autopagosome map + FADD@Cytosol map + Caspase8,10*|​ubi|​active@Cytosol map → map ATG5:​Caspase8,10*|​ubi:​FADD@Autopagosome map
As Catalyser:
  1. Caspase8*@Cytosol map → map cleaved~Caspase8*@Cytosol map
  2. Caspase10*@Cytosol map → map cleaved Caspase 10*@Cytosol map