Identifiers
NAME:Caspase8,10*:DAXX:FADD:FAF1:FAS:FASLG:FLASH*:RIPK1
References
10*:FLASH*:RIPK1:FAF1:FADD:DAXX:FASLG:FAS
Apoptosis complex led by FAS ligation
PMID:12702723
PMID:9184224
PMID:23069999
PMID:16498403
the subcellular localization and internalization pathways of CD95 play important roles in controlling activation of distinct signaling cascades to determine divergent cellular fates
rc_re1674( Regulated Cell Death ):
caspase-8 formed triple complex with TRAF2 and FLASH. Taken together, these results suggest that endogenous caspase-8 mediates TNF-alpha-induced activation of NF-kappaB via FLASH
rc_re1820( Regulated Cell Death ):
PMID:18545270
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
PMID:14744430
caspase-8 is polyubiquitylated at the DISC in response to Apo2L/TRAIL
PMID:20531300
PMID:19427028
The ubiquitin-binding protein p62/sequestosome-1 promoted aggregation of CUL3-modified caspase-8 within p62-dependent foci, leading to full activation and processing of the enzyme and driving commitment to cell death
+ Caspase8,10*:FLASH*@Cytosol + FAF1@Cytosol + FADD@Cytosol + DAXX@Cytosol + RIPK1@Cytosol → Caspase8,10*|ubi:DAXX:FADD:FAF1:FASLG:FAS|pal:FLASH*:RIPK1@Endosome
→ CFLAR:Caspase8,10*|ubi:FADD:FAF1:FASLG:FAS|pal:FLASH*:MLKL:RIPK1|emp|S161_pho:RIPK3|S199_pho@Endosome
→ Caspase8,10*|ubi:DAXX:FADD:FAF1:FASLG:FAS|pal:FLASH*:RIPK1@Endosome
→ rc_s6308