Identifiers
NAME:RIPK1:RIPK3
References
PMID:23010170
RIP1 deubiquitination leads to the formation of complex II which is composed of TRADD, FADD, RIP1 and caspase-8
PMID:23073834
PMID:22421439
PMID:12887920
If caspase 8 is inhibited, necroptosis is triggered.
rc_re1525( Regulated Cell Death ):
PMID:19498109
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.
rc_re1680( Regulated Cell Death ):
PMID:15592525
endogenous caspase-8 mediates TNF-alpha-induced activation of NF-kappaB via FLASH
rc_re1526( Regulated Cell Death ):
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.
MLKL functions downstream of RIP1 and RIP3 and is recruited to the necrosome through its interaction with RIP3
new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI
PMID:19632174
RIP3 directly interacts with glycogen phosphorylase (PYGL), glutamate ammonia ligase (GLUL), and glutamate dehydrogenase 1 (GLUD1
PMID:20823910
Molecular mechanisms of necroptosis: an ordered cellular explosion
PMID:27959630
PMID:26024392
The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis.
+ RIPK1|S161_pho@TNFRSF1 Receptor Complex + FADD@Cytosol → RIPK1|S161_pho:RIPK3|S199_pho@Cytosol
+ MLKL@Cytosol + GLUL@Cytosol + GLUD1@Cytosol + PYGL@Cytosol + PGAM5@Cytosol → GLUD1:GLUL:MLKL|S358_pho|T357_pho:PGAM5|pho:PYGL:RIPK1|S161_pho:RIPK3|S199_pho|S227_pho@Cytosol
→ RIPK1|S161_pho:RIPK3|S199_pho@Cytosol
→ RIPK1|S161_pho:RIPK3|S199_pho@Cytosol