Protein FLASH* map

Identifiers
caspase 8 associated protein 2
HUGO:CASP8AP2 HGNC:1510 ENTREZ:9994 UNIPROT:Q9UKL3

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map

References
PMID:22427918
FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival
PMID:12702723
PMID:15592525
PMID:1134007

FLASH*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map

Modifications:
In compartment: Cytosol
  1. FLASH*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. Caspase8,10*:​FLASH*@Cytosol map
  2. Caspase8*|​ubi:​FLASH*@Cytosol map
In compartment: Endosome
  1. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  2. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  3. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map
Participates in reactions:
As Reactant or Product:
  1. FLASH*@Cytosol map + Caspase8,10*@Cytosol map → map Caspase8,10*:​FLASH*@Cytosol map
  2. FASLG:​FAS|​pal@Cytosol map + Caspase8,10*:​FLASH*@Cytosol map + FAF1@Cytosol map + FADD@Cytosol map + DAXX@Cytosol map + RIPK1@Cytosol map → map Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  3. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  4. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map
  5. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map
  6. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map ASK1*@Cytosol map
  7. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  8. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  9. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map Caspase8*|​ubi:​FLASH*@Cytosol map
  10. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map → map rc_s6308
As Catalyser:
  1. CHUK:​IKBKG:​IKK_beta_*@TNFRSF1 Receptor Complex map → map CHUK:​IKBKG:​IKK_beta_*|​pho@TNFRSF1 Receptor Complex map