Identifiers
HUGO:IKBKG
inhibitor of nuclear factor kappa B kinase subunit gamma
HUGO:IKBKG hgnc_id:HGNC:5961 HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / TNF_RESPONSE
Regulated Cell Death / TRAIL_RESPONSE
Regulated Cell Death / ER_STRESS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:12133805
PMID:20138012
To determine whether the tumor-promoting activity of the fibroblasts was dependent on NF-??B, we knocked down Ikk?? in CAFs using shRNA (Figure 5C). Knockdown of IKK?? did not have an effect in vitro on CAF survival (data not shown). IKK??-shRNA CAFs were then coinjected orthotopically with PDSC5 cells. Tumors coinjected with shRNA IKK?? fibroblasts grew significantly slower than did tumors coinjected with control fibroblasts
PMID:23430059
NEMO
PMID:17485448
TNIP3 (ABIN3???) ???inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of??? ???FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream??? ???NFkB??? ???signaling??? ???downstream of IL10.
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / TNF_RESPONSE
Regulated Cell Death / TRAIL_RESPONSE
References
rc_re1654( Regulated Cell Death ):
PMID:9430228
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
PMID:16166346
TRAIL promotes cell migration and invasion via a NF-kappaB-dependent pathway in human cholangiocarcinoma cell lines
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / TNF_RESPONSE
Regulated Cell Death / TRAIL_RESPONSE
References
rc_re1215( Regulated Cell Death ):
PMID:16603398
PMID:23010170
K63-linked polyubiquitination of RIP1 provides a scaffold for the recruitment of TGF-beta-activated kinase 1 (TAK1) binding protein 2 and 3 (TAB2 and 3),
which finally activates TAK1
→ IKBKG|ubi:IKK_alpha_*:IKK_beta_*|pho@T_cell
→ IKBKG|ubi:IKK_alpha_*:IKK_beta_*|pho@Cytosol
→ IKBKG|ubi:IKK_alpha_*:IKK_beta_*|pho@INNATE_IMMUNE_CELL_Cytosol
+ TNIP3@INNATE_IMMUNE_CELL_Cytosol → IKBKG:IKK_alpha_*:IKK_beta_*:TNIP3@INNATE_IMMUNE_CELL_Cytosol
→ IKBKG@TNFRSF1 Receptor Complex
+ CHUK@Cytosol + IKBKG@TNFRSF1 Receptor Complex → CHUK:IKBKG:IKK_beta_*@TNFRSF1 Receptor Complex
→ CHUK:IKBKG:IKK_beta_*|pho@TNFRSF1 Receptor Complex
+ TRAF2@Cytosol + IKBKG@Cytosol + TRADD@Cytosol + RIPK1@Cytosol → Caspase10*:Caspase8*@Cytosol
→ Survival@Cytosol
→ IkB*|pho:NFKB1_p50*:RELA@T_cell
→ IkB*|pho:NFKB1_p50*:RELB@T_cell
→ IkB*|pho:NFKB1_p50*:cREL*@T_cell
→ BCL10|pho@T_cell
→ IkB*|pho:NFKB1_p50*:RELA@Cytosol
→ IkB*|pho:NFKB1_p50*:RELB@Cytosol
→ rTNF@INNATE_IMMUNE_CELL_Cytosol
→ rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
→ rIL8*@INNATE_IMMUNE_CELL_Cytosol
→ rIL6@INNATE_IMMUNE_CELL_Cytosol
→ STAT1|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ IkB*|pho:NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol
→ IkB*|pho:NFKB1_p50*:RELB@INNATE_IMMUNE_CELL_Cytosol
→ IkB*|pho:NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p105*|pho@INNATE_IMMUNE_CELL_Cytosol + MAP3K8@INNATE_IMMUNE_CELL_Cytosol + TNIP2@INNATE_IMMUNE_CELL_Cytosol
→ NFKBIA|pho@Cytosol