Identifiers
Fas associated via death domain
HUGO:FADD hgnc_id:HGNC:3573 HGNC:3573 ENTREZ:8772 UNIPROT:Q13158
Fas (TNFRSF6)-associated via death domain
HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / INFLAMMATORY_SIGNALING_PATHWAYS 
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FAS_RESPONSE 
 Regulated Cell Death   / GLUTAMINE_METABOLISM 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / TNF_RESPONSE 
 Regulated Cell Death   / TRAIL_RESPONSE 
 Regulated Cell Death   / ER_STRESS 

References
PMID:26587781
PMID:9488730
PMID:20531300
PMID:28574505
PMID:11003656
PMID:26972597
FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis.

1. FADD@Cytosol

1. FADD@INNATE_IMMUNE_CELL_Cytosol

1. FADD@INNATE_IMMUNE_CELL_Membrane

1. ATG5:​Caspase8,10*|​ubi:​FADD@Autopagosome

1. ATG5:​CASP8|​K63_ubi:​FADD:​LC3*:​SQSTM1 @Autophgosome

1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Cytosol
2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Cytosol

1. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome
2. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome
3. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome

1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane
2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane

1. TNF@default + TNFR1*@Cytosol + TRADD@Cytosol + TRAF2@Cytosol + RIPK1@Cytosol + FADD@Cytosol → FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Cytosol
2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Cytosol → FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Cytosol
3. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane → FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane
4. TNF@default + TNFR1*@INNATE_IMMUNE_CELL_Membrane + TRADD@INNATE_IMMUNE_CELL_Membrane + TRAF2@INNATE_IMMUNE_CELL_Membrane + RIPK1@INNATE_IMMUNE_CELL_Membrane + FADD@INNATE_IMMUNE_CELL_Membrane → FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane
5. TRADD@TNFRSF1 Receptor Complex + RIPK1@TNFRSF1 Receptor Complex + FADD@Cytosol → rc_s4026
6. RIPK3|​S199_pho@TNFRSF1 Receptor Complex + RIPK1|​S161_pho@TNFRSF1 Receptor Complex + FADD@Cytosol → RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol
7. FADD@Cytosol → FADD@Cytosol
8. DR4/5*:​TRAIL*@Cytosol + FADD@Cytosol → rc_s5142
9. FASLG:​FAS|​pal@Cytosol + Caspase8,10*:​FLASH*@Cytosol + FAF1@Cytosol + FADD@Cytosol + DAXX@Cytosol + RIPK1@Cytosol → Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome
10. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome → CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome
11. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome → ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome
12. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome → RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol
13. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome → ASK1*@Cytosol
14. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome → Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome
15. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome → CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome
16. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome → Caspase8*|​ubi:​FLASH*@Cytosol
17. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome → rc_s6308
18. ATG5@Autopagosome + FADD@Cytosol + Caspase8,10*|​ubi|​active@Cytosol → ATG5:​Caspase8,10*|​ubi:​FADD@Autopagosome
19. rc_s7530 + FADD@Cytosol → rc_s7531
20. rc_s7531 + SQSTM1 @Autophgosome + LC3*@Autophgosome + ATG5@Autophgosome → ATG5:​CASP8|​K63_ubi:​FADD:​LC3*:​SQSTM1 @Autophgosome
21. ATG5:​CASP8|​K63_ubi:​FADD:​LC3*:​SQSTM1 @Autophgosome → Apoptosis@Cytosol

1. IKBKG:​IKK_alpha_*:​IKK_beta_*@Cytosol → IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@Cytosol
2. MAP3K7@Cytosol + TAB2@Cytosol + TAB3@Cytosol → (MAP3K7:​TAB2:​TAB3)|​active@Cytosol
3. JNK*@Cytosol → JNK*|​pho|​active@Cytosol
4. ERK1/2*@Cytosol → ERK1/2*|​pho@Cytosol
5. MAP3K7@INNATE_IMMUNE_CELL_Cytosol + TAB2@INNATE_IMMUNE_CELL_Cytosol + TAB3@INNATE_IMMUNE_CELL_Cytosol → (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol
6. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol → IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol
7. JNK*@INNATE_IMMUNE_CELL_Cytosol → JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
8. p38*@INNATE_IMMUNE_CELL_Cytosol → p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
9. Sphingomyelin@Cytosol + H2O@Cytosol → Ceramide@Cytosol + Choline Phosphate@Cytosol
10. Caspase8*@Cytosol → cleaved~Caspase8*@Cytosol
11. Caspase10*@Cytosol → cleaved Caspase 10*@Cytosol