CFLAR:Caspase8,10*:FADD:FAF1:FAS:FASLG:FLASH*:MLKL:RIPK1:RIPK3

Complex CFLAR:Caspase8,10*:FADD:FAF1:FAS:FASLG:FLASH*:MLKL:RIPK1:RIPK3

Complex composition:

Identifiers
NAME:CFLAR:Caspase8,10*:FADD:FAF1:FAS:FASLG:FLASH*:MLKL:RIPK1:RIPK3

References
10*:RIPK3:CFLAR:FLASH*:RIPK1:FAF1:FADD:MLKL:FASLG:FAS
Fas Ligation can lead to Programmed necrosis
PMID:23069999
PMID:9217161
FLIPs and FLIP(L) interact with the adaptor protein FADD and the protease FLICE, and potently inhibit apoptosis induced by all known human death receptors
PMID:22427918
FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival
PMID:15592525
endogenous caspase-8 mediates TNF-alpha-induced activation of NF-kappaB via FLASH

Modifications:
Participates in complexes:
In compartment: Endosome

CFLAR:Caspase8,10*|ubi:FADD:FAF1:FASLG:FAS|pal:FLASH*:MLKL:RIPK1|emp|S161_pho:RIPK3|S199_pho@Endosome

Participates in reactions:
As Reactant or Product:

As Catalyser: