Identifiers
TNFRSF1A associated via death domain
HUGO:TRADD hgnc_id:HGNC:12030 HGNC:12030 ENTREZ:8717 UNIPROT:Q15628
HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628
HUGO:TRADD

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / INFLAMMATORY_SIGNALING_PATHWAYS 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / TNF_RESPONSE 
 Regulated Cell Death   / TRAIL_RESPONSE 
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 

References
PMID:21232017; PMID:18641653
TRADD is an adaptor molecule important for transducing signals from TNFR1. After binding of TNF, TRADD is recruited to TNFR1 and interacts with the cytoplasmic death domain region of TNFR1 through homotypic interactions. The TNFR1-TRADD complex serves as scaffolding for the recruitment of other signaling molecules that mediate the downstream actions of TNF.
PMID:14730360
Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins.
PMID:11274345

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / TNF_RESPONSE 
 Regulated Cell Death   / TRAIL_RESPONSE 

References
rc_re1326( Regulated Cell Death  ):
PMID:18292600
AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation
PMID:10734135
PMID:8974401
PMID:15310755
rc_re1334( Regulated Cell Death  ):
PMID:23010170
TRADD recruits FADD and caspase-8, forming complex IIA, where caspase-8 is activated and apoptosis is initiated
PMID:12887920
rc_re1343( Regulated Cell Death  ):
PMID:17560373
PMID:19641494

References
su_mpk1_mpk1_re121( Survival  ):
Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins.
PMID:11274345

1. TRADD@Cytoplasm

1. TRADD@Cytosol

1. TRADD@INNATE_IMMUNE_CELL_Membrane

1. TRADD@TNFRSF1 Receptor Complex

1. RIPK1:​TAK1*|​pho:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm
2. MAP3K1|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm
3. MAP3K5|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm
4. MAP3K2_3*|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm

1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Cytosol
2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Cytosol

1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane
2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane

1. TNFRSF1A:​TRADD@Plasma Membrane
2. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane
3. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane

1. TNF@default + TNFR1*@Cytosol + TRADD@Cytosol + TRAF2@Cytosol + RIPK1@Cytosol + FADD@Cytosol → FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Cytosol
2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Cytosol → FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Cytosol
3. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane → FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane
4. TNF@default + TNFR1*@INNATE_IMMUNE_CELL_Membrane + TRADD@INNATE_IMMUNE_CELL_Membrane + TRAF2@INNATE_IMMUNE_CELL_Membrane + RIPK1@INNATE_IMMUNE_CELL_Membrane + FADD@INNATE_IMMUNE_CELL_Membrane → FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane
5. TRADD@Cytosol → TRADD@TNFRSF1 Receptor Complex
6. DAB2IP|​S604_pho@TNFRSF1 Receptor Complex + TRAF2@TNFRSF1 Receptor Complex + TRADD@TNFRSF1 Receptor Complex → rc_s4171
7. TRADD@TNFRSF1 Receptor Complex + RIPK1@TNFRSF1 Receptor Complex + FADD@Cytosol → rc_s4026
8. Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol + TRAF2@Cytosol + IKBKG@Cytosol + TRADD@Cytosol + RIPK1@Cytosol → Caspase10*:​Caspase8*@Cytosol
9. TNFRSF1A@Plasma Membrane + TRADD@Cytoplasm → TNFRSF1A:​TRADD@Plasma Membrane
10. TRAF2@Cytoplasm + TNFRSF1A:​TRADD@Plasma Membrane → TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane
11. RIPK1@Cytoplasm + TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane → RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane
12. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane + TAK1*@Cytoplasm → RIPK1:​TAK1*|​pho:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm
13. MAP3K1@Cytoplasm + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane → MAP3K1|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm
14. MAP3K2_3*@Cytoplasm + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane → MAP3K2_3*|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm
15. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane → ROS@Cytoplasm
16. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane + MAP3K5@Cytoplasm → MAP3K5|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm

1. IKBKG:​IKK_alpha_*:​IKK_beta_*@Cytosol → IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@Cytosol
2. MAP3K7@Cytosol + TAB2@Cytosol + TAB3@Cytosol → (MAP3K7:​TAB2:​TAB3)|​active@Cytosol
3. JNK*@Cytosol → JNK*|​pho|​active@Cytosol
4. ERK1/2*@Cytosol → ERK1/2*|​pho@Cytosol
5. MAP3K7@INNATE_IMMUNE_CELL_Cytosol + TAB2@INNATE_IMMUNE_CELL_Cytosol + TAB3@INNATE_IMMUNE_CELL_Cytosol → (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol
6. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol → IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol
7. JNK*@INNATE_IMMUNE_CELL_Cytosol → JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
8. p38*@INNATE_IMMUNE_CELL_Cytosol → p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
9. RIPK1@Cytosol → RIPK1@TNFRSF1 Receptor Complex
10. RFK@Cytosol → RFK@TNFRSF1 Receptor Complex
11. MAP2K4@Cytoplasm → MAP2K4|​pho|​pho@Cytoplasm
12. MAP2K3@Cytoplasm → MAP2K3|​pho|​pho@Cytoplasm
13. MAP2K7@Cytoplasm → MAP2K7|​pho|​pho@Cytoplasm
14. MAP2K6@Cytoplasm → MAP2K6|​pho|​pho@Cytoplasm
15. MEK*@Cytoplasm → MEK*|​pho|​pho@Cytoplasm