Reaction state_transition rc_re1674 map

FASLG:​FAS|​pal@Cytosol map + Caspase8,10*:​FLASH*@Cytosol map + FAF1@Cytosol map + FADD@Cytosol map + DAXX@Cytosol map + RIPK1@Cytosol map → Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map

Reaction regulators:
Catalysis
  1. SQSTM1@Endosome map
Inhibition
  1. PTPN13@Cytosol map
  2. FAIM@Cytosol map


References
Apoptosis complex led by FAS ligation
PMID:12702723
PMID:9184224
PMID:23069999
PMID:16498403
caspase-8 formed triple complex with TRAF2 and FLASH. Taken together, these results suggest that endogenous caspase-8 mediates TNF-alpha-induced activation of NF-kappaB via FLASH