Identifiers
HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14

Maps_Modules
MODULE:MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS

References
REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11
REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12
REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13
REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14
PMID:11875494
IL10-induced p38 phosphorylation.
PMID:20435894
SHIP inhibit MAPKp38 activation and prevent
MKNK1 phosphorylation by inhibiting the p38MAPK
pathway downstream of IL10.
PMID:10925299
IL13 induces p38 MAPK phosphorilation and activation,
p38 MAPK participates in arginase activation??downstream of IL13
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling. TLR activation of CREB by phosphorylation of serine-133 is dependent on p38.

Identifiers

Maps_Modules

References

Identifiers

Maps_Modules

References

1. p38*@Cytosol
2. p38*|​pho|​active@Cytosol

1. p38*@Cytosol → p38*|​pho|​active@Cytosol

1. L-arginine@Cytosol → Urea@Cytosol + L-ornitine@Cytosol
2. STAT1@Cytosol → STAT1|​pho|​active@Cytosol
3. CREB1@Cytosol → CREB1|​pho|​active@Cytosol
4. RELA@Cytosol + NFKB1_p50*@Cytosol → NFKB1_p50*:​RELA|​pho@Cytosol
5. gHMOX1@Cytosol → rHMOX1@Cytosol
6. MKNK1@Cytosol → MKNK1|​pho|​active@Cytosol