Simple molecule PIP3* map
PIP3*@Cytosol

Identifiers

Maps_Modules

References
PMID:11687500
PI3K converts phosphatidylinositol 4,5-biphosphate ( PI(4,5)P 2 ) to phosphatidylinositol 3,4,5-triphosphate ( PI(3,4,5)P 3 ), which is secondary messenger involved the in regulation of various process .
SHIP catalyzes the conversion of PIP3 to PI(3,4)P2. It is a negative regulators of PI3K pathway.
PMID:21469115
SHIP inhibits PI3K signaling and prevents M2 polarisation downstream of IL4,
But IL4 signaling reduces SHIP protein levels and activity via PI3K correlating with M2 marker induction ( activation of arginase protein level and activity and inhibition of NO production).

Modifications:
In compartment: Cytosol
  1. PIP3*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. PDPK1:​PIP3*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PIP2*@Cytosol map → map PIP3*@Cytosol map
  2. PIP3*@Cytosol map + PDPK1@Cytosol map → map PDPK1:​PIP3*@Cytosol map
  3. PIP3*@Cytosol map → map PIP2*@Cytosol map
As Catalyser:
  1. AKT*@Cytosol map → map AKT*|​pho|​active@Cytosol map
  2. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map
  3. SHIP1*@Cytosol map → map degraded